MBSR for Pain Catastrophizing in SCD
| Status: | Completed |
|---|---|
| Conditions: | Anemia |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/31/2017 |
| Start Date: | April 2015 |
| End Date: | January 2016 |
A Mindfulness-based Intervention For Pain Catastrophizing In Sickle Cell Disease
Significance: The purpose of this exploratory study is to test the feasibility,
accessibility, and effects of a mindfulness-based stress reduction program (MBSR) on reducing
pain catastrophizing in persons with sickle cell disease (SCD) and chronic pain. One of the
most difficult symptoms for SCD patients to manage is chronic pain. Approximately one-third
of SCD patients experience chronic pain, which is associated with pain catastrophizing. Pain
catastrophizing is a negative mental state toward pain stimuli and pain experience, and is
associated with increased pain severity, pain interference, and lower social functioning,
physical functioning, and mental health. There have been no psychobehavioral intervention
studies that have attempted to alter the experience of pain catastrophizing in persons with
SCD. MBSR is a complementary group-based therapy that emphasizes nonjudgmental awareness of
thoughts, feelings, and bodily sensations. With no pharmacological or non-pharmacological
treatment for catastrophizing in persons with SCD, MBSR offers a potential solution to this
highly significant problem for both SCD patients and providers. This project will be the
first randomized controlled trial (RCT) of MBSR to reduce pain catastrophizing, and improve
quality of life for SCD patients with chronic pain.
Methods: This study will enroll 60 adult patients with SCD and chronic pain from the Duke
Adult Sickle Cell Clinic. Patients will be randomized to a MBSR or wait-listed control group.
The MBSR group will complete a 6- week, group-based telephonic MBSR program that is
administered by a certified MBSR clinician once a week for 90 minutes. MBSR feasibility,
acceptability, and effects on pain catastrophizing will be assessed by questionnaires at
baseline, week 1, 3, and 6 in both groups. At the end of week 6, 10 randomly selected MBSR
participants will complete semi-scripted telephone interviews to help assess intervention
acceptability, and the wait-listed control condition will be offered the same MBSR
intervention.
accessibility, and effects of a mindfulness-based stress reduction program (MBSR) on reducing
pain catastrophizing in persons with sickle cell disease (SCD) and chronic pain. One of the
most difficult symptoms for SCD patients to manage is chronic pain. Approximately one-third
of SCD patients experience chronic pain, which is associated with pain catastrophizing. Pain
catastrophizing is a negative mental state toward pain stimuli and pain experience, and is
associated with increased pain severity, pain interference, and lower social functioning,
physical functioning, and mental health. There have been no psychobehavioral intervention
studies that have attempted to alter the experience of pain catastrophizing in persons with
SCD. MBSR is a complementary group-based therapy that emphasizes nonjudgmental awareness of
thoughts, feelings, and bodily sensations. With no pharmacological or non-pharmacological
treatment for catastrophizing in persons with SCD, MBSR offers a potential solution to this
highly significant problem for both SCD patients and providers. This project will be the
first randomized controlled trial (RCT) of MBSR to reduce pain catastrophizing, and improve
quality of life for SCD patients with chronic pain.
Methods: This study will enroll 60 adult patients with SCD and chronic pain from the Duke
Adult Sickle Cell Clinic. Patients will be randomized to a MBSR or wait-listed control group.
The MBSR group will complete a 6- week, group-based telephonic MBSR program that is
administered by a certified MBSR clinician once a week for 90 minutes. MBSR feasibility,
acceptability, and effects on pain catastrophizing will be assessed by questionnaires at
baseline, week 1, 3, and 6 in both groups. At the end of week 6, 10 randomly selected MBSR
participants will complete semi-scripted telephone interviews to help assess intervention
acceptability, and the wait-listed control condition will be offered the same MBSR
intervention.
Inclusion Criteria:
1. Provide written informed consent,
2. Are >age 21,
3. Self-identify (to the PI at baseline assessment) that they are experiencing chronic,
non-cancer pain that has persisted on most days for more than 6 months, and adversely
affects their function or well-being,
4. are able to speak and read English,
5. Have access to a telephone (or cell phone) in the home for the intervention and
individual assessment interviews (data from the SCD clinic indicate 82% of patients
have a cell phone),
6. Have access to a CD or mp3 player for homework assignments and daily practice,
7. Are available during the scheduled telephone intervention, and
8. Complete and return the baseline assessment
Exclusion Criteria:
- Patients will be excluded if they report previously studying MBSR, currently receiving
mindfulness-based or cognitive behavioral therapies, or being regular practitioners of
mindfulness, including yoga.
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