Temperature Evaluation by MRI Thermometry During Cervical Cooling
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 4/2/2016 |
| Start Date: | April 2015 |
| End Date: | December 2015 |
| Contact: | Daniel Wolfson, MD |
| Email: | Daniel.Wolfson@state.vt.us |
| Phone: | (802) 847-2434 |
The American Heart Association (AHA) recommends cooling (inducing mild hypothermia) patients
who were resuscitated following cardiac arrest but who remained comatose. Induced mild
hypothermia is now the standard of care for post-resuscitation patients in the intensive
care unit (ICU) setting. The use of cooling has recently moved to pre-hospital and emergency
department (ED) application as more current studies show that early initiation of cooling
significantly improves neurologic outcomes and survival rates instead of waiting until the
patient arrives in the ICU to initiate cooling. In the pre-hospital setting chilled saline
(4°C) and packing the body in ice have been the primary methods to initiate induced mild
hypothermia The Excel Cryo Cooling System is a non-invasive cervical collar (C-collar) that
provides cooling to the carotid arteries, the main blood supply to the brain, and allows for
the rapid initiation of selective cerebral cooling. The investigators are planning to use
MRI-thermometry to see how quickly the Excel Cryo Cooling Collar can drop brain temperature
when applied by itself.
Healthy volunteers will be used for this study to provide important temperature data on the
effectiveness of the Excel Cryo Cooling System. The investigators will be able to use the
data from this project to further the current clinical research in induced mild hypothermia
after cardiac arrest.
who were resuscitated following cardiac arrest but who remained comatose. Induced mild
hypothermia is now the standard of care for post-resuscitation patients in the intensive
care unit (ICU) setting. The use of cooling has recently moved to pre-hospital and emergency
department (ED) application as more current studies show that early initiation of cooling
significantly improves neurologic outcomes and survival rates instead of waiting until the
patient arrives in the ICU to initiate cooling. In the pre-hospital setting chilled saline
(4°C) and packing the body in ice have been the primary methods to initiate induced mild
hypothermia The Excel Cryo Cooling System is a non-invasive cervical collar (C-collar) that
provides cooling to the carotid arteries, the main blood supply to the brain, and allows for
the rapid initiation of selective cerebral cooling. The investigators are planning to use
MRI-thermometry to see how quickly the Excel Cryo Cooling Collar can drop brain temperature
when applied by itself.
Healthy volunteers will be used for this study to provide important temperature data on the
effectiveness of the Excel Cryo Cooling System. The investigators will be able to use the
data from this project to further the current clinical research in induced mild hypothermia
after cardiac arrest.
Inclusion Criteria:
- > 18 years of age
- Understands the risks involved, as detailed in the informed consent
- No MRI risk factors
Exclusion Criteria:
- < 18 years of age & > 60 years of age
- Pregnant
- Any known medical problems that limit activity or decrease blood flow: underactive
thyroid (hypothyroidism),poor nutrition, stroke, severe arthritis, Parkinson's
disease, dementia, significant mental illness besides clinical depression, spinal
cord injuries, recent serious burn, disorders that affect sensation in the
extremities (e.g., diabetic neuropathy)dehydration, and any condition that limits
activity or restrains the normal flow of blood.
- Taking any medications (except seasonal allergy medication, over-the-counter NSAIDs,
acetaminophen, or contraceptives)
- Oral medications that inhibit the body's ability to respond to cold: Antidepressants,
antipsychotics/neuroleptics, including phenothiazines, beta blockers, clonidine,
meperidine, sedative-hypnotics.
- History of cardiac condition in a family member younger than 40 years
- Inability to fit in the MRI scanner (BMI > 30 kg/m2)
- MRI risk factors (e.g., claustrophobia, heart condition, metal implants, etc), as
detailed in the MRI safety questionnaire Heart rate, blood pressure, respiratory
rate, or temperature outside of acceptable ranges.
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