A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic CRPC



Status:Terminated
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/30/2017
Start Date:June 2015
End Date:November 2016

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Trial Summary
Trial Overview
Inclusion Criteria

ARMOR3-SV: A Phase 3, Randomized, Open Label, Multi-Center, Controlled Study of Galeterone Compared to Enzalutamide in Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic (M1) Castrate Resistant Prostate Cancer (CRPC)

The purpose of this study is to compare galeterone to enzalutamide in men expressing androgen
receptor spice variant-7 mRNA (AR-V7) in metastatic (M1) castrate resistant prostate cancer
(CRPC).


Inclusion Criteria:

- Progressive metastatic (M1) disease on androgen deprivation therapy

- Detectable AR-V7 from circulating tumors (CTCs)

- ECOG performance status 0 or 1

Exclusion Criteria:

- Prior treatment with second generation anti-androgens (e.g. abiraterone, enzalutamide)

- Prior treatment with chemotherapy for CRPC
We found this trial at
52
sites
The Urology Group
Cincinnati, Ohio 45212
Principal Investigator: Igor Dumbadze
Phone: 513-841-7555
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland 21231
410-955-6190
Principal Investigator: Emmanuel Antonarakis
Phone: 410-955-6743
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
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Boca Raton Community Hospital
800 8th Street
Boca Raton, Florida 33486
Principal Investigator: Alan Koletsky
Phone: 561-955-3719
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Mary Ellen Taplin
Phone: 617-582-7334
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Boston, MA
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Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Mary Ellen Taplin
Phone: 617-632-9289
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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University of Michigan Health System
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
Principal Investigator: Maha Hussain
Phone: 800-865-1125
University of Michigan Health System The University of Michigan is home to one of the...
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University of Colorado Cancer Center Anschultz Cancer Pavilion
Aurora, Colorado 80045
Principal Investigator: Thomas Flaig
Phone: 720-848-0659
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Aurora, CO
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University of Maryland Greenenbaum Cancer Center
Baltimore, Maryland 21201
Principal Investigator: Arif Hussain
Phone: 410-328-8610
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Baltimore, MD
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Walter Reed National Military Medical Center
8901 Rockville Pike
Bethesda, Maryland 20889
(301) 295-4000
Principal Investigator: David McLeod
Phone: 301-319-2923
Walter Reed National Military Medical Center The Walter Reed National Military Medical Center is one...
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Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Mary Ellen Taplin
Phone: 617-582-7334
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Coastal Urology Associates
446 Jack Martin Boulevard
Bricktown, New Jersey 08724
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Bricktown, NJ
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Brooklyn Urology Research Group
Brooklyn, New York 11215
Principal Investigator: Ivan Grunberger
Phone: 718-230-1202
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University of North Carolina- Lineberger Cancer Center
Chapel Hill, North Carolina 27599
Principal Investigator: Young Whang
Phone: 919-445-4212
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Chapel Hill, NC
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Carolina Urology Partners, PLLC
Charlotte, North Carolina 28277
Principal Investigator: Robert Waterhouse
Phone: 704-864-7764
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Charlotte, NC
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Carolina Urology Partners, PLLC
Concord, North Carolina 28025
Principal Investigator: David Lipsitz
Phone: 704-578-2609
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Concord, NC
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Urology Clinics of North Texas
Dallas, Texas 75231
Principal Investigator: James Cochran
Phone: 214-580-1391
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Dallas, TX
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Texas Oncology/Baylor University Medical Center
Dallas, Texas 75246
Principal Investigator: Thomas Hutson
Phone: 214-370-1846
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Dallas, TX
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Urology Center of Colorado
Denver, Colorado 80211
Principal Investigator: Lawrence Karsh
Phone: 303-421-5783
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Karmanos Cancer Center
Detroit, Michigan 48202
Principal Investigator: Elisabeth Heath
Phone: 313-576-8717
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Detroit, MI
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City of Hope
Duarte, California 91010
Principal Investigator: Przemyslaw Twardowski
Phone: 626-256-4673
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First Urology
Jeffersonville, Indiana 47130
Principal Investigator: James Bailen
Phone: 812-206-8162
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Jeffersonville, IN
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St. George Private Hospital, Oncology Day Care Centre
Kogarah, New South Wales 2217
Principal Investigator: Paul de Souza
Phone: (02) 9598 5310
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Lancaster Urology
Lancaster, Pennsylvania 17604
Principal Investigator: Paul Sieber
Phone: 717-431-2285
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Lancaster, PA
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U.S.C./Norris Comprehensive Cancer Center
1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Principal Investigator: David Quinn
Phone: 323-865-0843
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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UCLA Jonsson Comprehensive Cancer Center
Los Angeles, California 90095
Principal Investigator: Allan Pantuck
Phone: 310-794-3550
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University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin 53792
Principal Investigator: Liu Glenn
Phone: 800-622-8922
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Madison, WI
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Prostate Oncology Specialists, Inc.
Marina Del Rey, California 90292
Principal Investigator: Mark Scholz
Phone: 310-827-7707
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Marina Del Rey, CA
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Clinical Research Solutions, LLC
Middleburg Heights, Ohio 44130
Principal Investigator: Lawrence Gervasi
Phone: 440-525-0211
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Middleburg Heights, OH
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Carolina Urologic Research Center
823 82nd Parkway, Suite B
Myrtle Beach, South Carolina 29572
(843) 449-1010 ext.268
Principal Investigator: Neal Shore
Phone: 843-839-1679
Carolina Urologic Research Center Carolina Urologic Research Center (CURC) has been recognized both nationally and...
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Urology Associates Clinical Research
Nashville, Tennessee 37209
Principal Investigator: Raoul Concepcion
Phone: 615-250-9268
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Yale University School of Medicine
333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Principal Investigator: Michael Hurwitz
Phone: 203-737-5428
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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Tulane Medical Center
New Orleans, Louisiana 70112
Principal Investigator: Brian Lewis
Phone: 504-988-6542
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New Orleans, LA
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Urology Cancer Center & GU Research Network
Omaha, Nebraska 68130
Principal Investigator: Luke Nordquist
Phone: 402-991-8468
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Omaha, NE
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University of Florida Health Cancer Center
Orlando, Florida 32806
Principal Investigator: Julio Hajdenberg
Phone: 321-841-4347
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Orlando, FL
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Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Principal Investigator: Yu-Ning Wong
Phone: 215-728-3614
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Philadelphia, PA
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UPMC Cancer Centers
Pittsburgh, Pennsylvania 15232
Principal Investigator: Leonard Appleman
Phone: 412-623-4891
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Advanced Urology Centers of New York
Plainview, New York 11803
Principal Investigator: Alfred Kohan
Phone: 516-433-0049
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Premier Medical Group of the Hudson Valley
243 N Rd
Poughkeepsie, New York 12601
(845) 471-9410
Principal Investigator: Evan Goldfischer
Phone: 845-437-5010
Premier Medical Group of the Hudson Valley Premier Medical Group offers comprehensive, integrated care providing...
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Poughkeepsie, NY
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Virginia Urology
Richmond, Virginia 23235
Principal Investigator: Michael Franks
Phone: 804-288-2785
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Richmond, VA
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UC Davis Cancer Center
Sacramento, California 95817
Principal Investigator: Primo Lara
Phone: 916-734-0162
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Sacramento, CA
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Urology San Antonio
San Antonio, Texas 78229
Principal Investigator: Daniel Saltzstein
Phone: 210-617-4116
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San Antonio, TX
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San Bernardino Urological Associates
San Bernardino, California
Principal Investigator: Franklin Chu
Phone: 909-881-0555
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San Bernardino, CA
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Pinnacle Oncology Hematology
Scottsdale, Arizona 85258
Principal Investigator: Michael Gordon
Phone: 480-860-5000
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Scottsdale, AZ
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Regional Urology
Shreveport, Louisiana 71106
Principal Investigator: Jonathon R. Henderson
Phone: 318-683-0411
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Shreveport, LA
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Oregon Urology Institute
Springfield, Oregon 97477
Principal Investigator: Bryan Mehlhaff
Phone: 541-284-5508
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Springfield, OR
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Associated Medical Professionals of NY
Syracuse, New York 13210
Principal Investigator: Chris Pieczonka
Phone: 315-478-4185
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Syracuse, NY
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Moffitt Cancer Center
Tampa, Florida 33612
Principal Investigator: Jingsong Zhang
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Tampa, FL
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Urology Speciality Group
Torrance, California 90505
Principal Investigator: Fredrick Wolk
Phone: 310-602-5018
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Torrance, CA
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University of Arizona Cancer Center
Tucson, Arizona 85724
Principal Investigator: Parminder Singh
Phone: 520-626-4403
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Tucson, AZ
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Urology of Virginia, PLLC
Virginia Beach, Virginia 23462
Principal Investigator: Robert Given
Phone: 757-457-5480
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Virginia Beach, VA
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Georgetown University Medical Center
Washington, D.C., District of Columbia 20007
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Sibley Memorial Hospital
Washington, D.C., District of Columbia 20016
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