Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease



Status:Active, not recruiting
Conditions:Anemia
Therapuetic Areas:Hematology
Healthy:No
Age Range:18 - 55
Updated:1/11/2019
Start Date:November 2014
End Date:December 2020

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Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue
due to their disease. The investigators are interested in how blood flow and cerebral
inflammation are different in SCA patients and how that affects brain tissue- the
investigators will use a relatively new set of dynamic MRI techniques to evaluate these
parameters. The investigators will image participants with both SCA and matched controls with
non-invasive MRI.

Patients with sickle cell anemia (SCA) are at increased risk for episodes of stroke, both
overt clinically evident and subclinical lesions only seen on imaging, which have associated
morbidity and mortality. In addition, SCA patients demonstrate relatively poorer cognitive
performance compared to their peers without SCA that is believed to be related to the
episodes of stroke, but may be present even in their absence.

This study is designed to explore potential risk factors in patients with SCA that will
identify predictors of cerebral damage that may also be modifiable. Elevated blood flow in
cerebral arteries and increased inflammation are believed to be related to both ischemic
lesions and cognitive findings but have not yet been clearly proven. We aim to use new MRI
techniques which target cerebral blood flow and inflammation to identify differences in SCA
patients and peers and follow this with an initial exploration of the association between
these pathologic findings and cognitive deficits.

The investigator does not assign specific interventions to the subjects of the study.

Inclusion Criteria:

- Patient with HbSS/HbSB0,

- age between 18 and 55 years or age/gender/race/education matched peer

Exclusion Criteria:

- Previous history of a stroke/transient ischemic attack,

- neurosurgery,

- head trauma,

- seizures,

- pulmonary embolism,

- deep-vein thrombosis,

- bleeding/clotting disorders,

- current or previous use of anticoagulation medications
We found this trial at
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Bronx, New York 10461
Principal Investigator: Henny H Billett, MD
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1300 Morris Park Ave
Bronx, New York 10461
(718) 430-2000
Principal Investigator: Henny H Billett, M.D.
Albert Einstein College of Medicine The Albert Einstein College of Medicine of Yeshiva University is...
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