RDEA3170 Tablet and Capsule Bioavailability Study

Inclusion Criteria:

- Subject is able to understand the study procedures and the risks involved, and is
willing to provide written informed consent before the first study-related activity.

- Subject has a body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 and ≤ 40
kg/m2.

- Subject has a Screening serum urate level of 4 to 7 mg/dL.

- Subject is free of any clinically significant disease or medical condition, per the
Investigator's judgment.

Exclusion Criteria:

- Subject has a history or suspicion of kidney stones.

- Subject has undergone major surgery within 3 months prior to Screening.

- Subject donated blood or experienced significant blood loss within 12 weeks prior to
Day 1 or gave a plasma donation within 4 weeks prior to Day 1.

- Subject has clinically unacceptable physical examination, per the Investigator's
judgment.

- Subject has clinically relevant abnormalities in blood pressure, heart rate, or body
temperature, per the Investigator's judgment.

- Subject has Screening clinical safety laboratory parameters (serum chemistry [other
than serum creatinine and serum urate], hematology, coagulation or urinalysis) that
are outside the normal limits and are considered clinically significant by the
Investigator.

- Subject has a serum creatinine value above the upper limit of normal at the Screening
visit.

- Subject has clinically relevant abnormalities in 12-lead electrocardiogram, per the
Investigator's judgment.

- Subject has a history of cardiac abnormalities

- Subject cannot swallow multiple tablets or capsules.

- Subject has received any strong or moderate enzyme-inducing drug or product within 2
months prior to Day 1.