The Effects of Nicotine Chewing Gum in Parkinson's Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2015 |
| Contact: | Joanne Donoghue, PhD |
| Email: | jdonoghu@nyit.edu |
| Phone: | 516-686-3759 |
The Effects of Nicotine Chewing Gum on Acute Low Blood Pressure in Parkinson's Disease
The objective of this experiment is:
To determine if nicotine chewing gum will improve acute episodes of orthostatic hypotension
in PD subjects.
To determine if nicotine chewing gum will improve acute episodes of orthostatic hypotension
in PD subjects.
Subjects will be asked to sit and rest for 10 minutes. Blood pressure will be taken in this
resting position after the 10 minutes.
After all inclusion criteria has been met, subjects will then wear an automated BP cuff and
be administered 4mg of nicotine gum (Nicorette™). They will be instructed to use it
according to manufacturer's directions and remain chewing the gum for 30 minutes. The
subject will remain in a seated position and BP and HR will be recorded every 5 minutes for
30 minutes. After 30 minutes the gum will be removed and subjects will still have HR and BP
monitored in the seated position for another hour every 10 minutes. All values will be
compared to pretreatment values. After 120 minutes if the subject is non-symptomatic, they
can go home.
resting position after the 10 minutes.
After all inclusion criteria has been met, subjects will then wear an automated BP cuff and
be administered 4mg of nicotine gum (Nicorette™). They will be instructed to use it
according to manufacturer's directions and remain chewing the gum for 30 minutes. The
subject will remain in a seated position and BP and HR will be recorded every 5 minutes for
30 minutes. After 30 minutes the gum will be removed and subjects will still have HR and BP
monitored in the seated position for another hour every 10 minutes. All values will be
compared to pretreatment values. After 120 minutes if the subject is non-symptomatic, they
can go home.
Inclusion Criteria:
- a diagnosis of PD
- a diastolic BP less than 90 mmHg
- and/or a systolic BP lower than 100mHg.
Exclusion Criteria:
- current tobacco users in all forms of tobacco
- severe dysphasia (difficulty swallowing)
- previous tobacco users who might be at risk for re-addiction.
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