A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole

Inclusion Criteria:

- Between 65 and 80 years of age at screening (inclusive)

- Healthy, as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and
cardiac monitoring or a subject with a clinical abnormality or laboratory parameters
outside the reference range for the population being studied may be included if the
investigator and the GlaxoSmithKline (GSK) Medical Monitor agree that the finding is
unlikely to introduce risk factors and will not interfere with the study procedures
and objectives.

- Body Mass Index between 19 and 34 (inclusive)

- Male or Female Males: Male subjects with female partners of child bearing potential
must comply with the following contraception requirements from the time of first dose
of study medication until a cycle of spermatogenesis following five terminal half-
lives after the last dose of study medication. a. Vasectomy with documentation of
azoospermia. b. Male condom plus partner use of one of the contraceptive options:
Contraceptive subdermal implant, Intrauterine device or intrauterine system, Oral
Contraceptive, either combined or progestogen alone Injectable progestogen,
Contraceptive vaginal ring, Percutaneous contraceptive patches.

This is an all-inclusive list of those methods that meet the following GSK definition of
highly effective: having a failure rate of less than 1% per year when used consistently and
correctly and, when applicable, in accordance with the product label. For non-product
methods (e.g., male sterility), the investigator determines what is consistent and correct
use. The GSK definition is based on the definition provided by the International Conference
on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human
Use (ICH). The investigator is responsible for ensuring that subjects understand how to
properly use these methods of contraception.

Females: A female subject is eligible to participate if she is not pregnant (as confirmed
by a negative urine human chorionic gonadotrophin [hCG] test), not lactating, and at least
one of the following conditions applies: Non-reproductive potential defined as: a.
Pre-menopausal females with one of the following: Documented tubal ligation, Documented
hysteroscopic tubal occlusion procedure with follow-up confirmation of bilateral tubal
occlusion, Hysterectomy, Documented Bilateral Oophorectomy. b. Postmenopausal defined as 12
months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous
follicle stimulating hormone (FSH) and estradiol levels consistent with menopause (refer to
laboratory reference ranges for confirmatory levels)]. Females on hormone replacement
therapy (HRT) and whose menopausal status is in doubt will be required to use one of the
highly effective contraception methods if they wish to continue their HRT during the study.
Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior
to study enrolment.

- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the consent form and in protocol.

- Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), alkaline phosphatase
and bilirubin <= 1.5 × Upper limit of normal (ULN) (isolated bilirubin > 1.5 × ULN is
acceptable if bilirubin is fractionated and direct bilirubin < 35%).

- Resting Blood pressure (BP) of <=160/90 millimetre (mm) mercury (Hg), irrespective of
anti-hypertensive medication status for the subject.

- Able to consume the Food and Drug Administration (FDA) defined high fat meal within 30
minutes in each of the four treatment periods where study treatment is administered in
a fed state

Exclusion Criteria:

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

- A positive pre-study Hepatitis B surface antigen (HBsAg) or positive Hepatitis C
antibody (HCV Ab) result within 3 months of screening.

- A positive pre-study drug/alcohol screen, with the exception of a positive result
considered by the investigator to be directly attributable to prescription medication
approved for subject use during the study.

- A positive test for human immunodeficiency virus (HIV) antibody.

- Use of prescription or non-prescription drugs, including proton pump inhibitors,
histamine receptor 2 antagonists, systemic antacid medications (unless these can be
held during the study), vitamins, herbal and dietary supplements (including St John's
Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5
half-lives (whichever is longer) prior to the first dose of study treatment until
completion of the last study assessment for Period 5, unless in the opinion of the
investigator and GSK Medical Monitor, the medication will not interfere with the study
procedures or compromise subject safety. Some examples of exceptions (permitted
medications) are: a. Stable dose of anti-hypertensive medication for at least 3 months
prior to the screening visit. b. Stable dose of lipid-lowering medications (statins or
fibrates) for at least 3 months prior to the screening visit. c. Antacids up to 24
hours prior to dosing This list is not meant to be all inclusive.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 3 months, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities (any investigational, non-marketed,
non-FDA-approved medicine) within 12 months prior to the first dosing day.

- History of regular alcohol consumption within 6 months of the study defined as:

An average weekly intake of >21 units for males or >14 units for females. One unit is
equivalent to 8 gram (g) of alcohol: a half-pint (approximately 240 millilitre [mL]) of
beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.

- Urine cotinine levels indicative of current smoking, or history or regular use of
tobacco- or nicotine-containing products, including e-cigarettes and nicotine patches,
within 90 days prior to screening.

- Consumption of red wine, Seville oranges, grapefruit or grapefruit juice and/or
pummelos, citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the
first dose of study treatment until collection of the final blood sample.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 3-month period.

- Unwillingness or inability to follow all of the procedures outlined in the protocol.

- Subject is mentally or legally incapacitated.

- Direct involvement in the conduct of the study, or relative of any person directly
involved in the conduct of the study.

- Female Subjects: Positive urine beta-hCG test at screening.

- Screening QT interval corrected for heart rate according to Fridericia's formula
(QTcF)> 450 millisecond (msec) or an ECG that is not suitable for QT measurements
(e.g., poorly defined termination of T-wave).

- History of sensitivity to any of the study treatments, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.