Immune-Related Trafficking and Signaling in Human Skin Associated With Low-Power, Infrared Laser Treatment
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/17/2018 |
| Start Date: | June 2015 |
| End Date: | March 2020 |
| Contact: | Brent Martin, MD |
| Email: | bcmartin@uci.edu |
| Phone: | 949.233-9060 |
The purpose of this is that the researcher can use low power Near Infrared laser treatment
non-painful and non-damaging dose to changes the skin properties.The researcher can prove
that signaling and a significant increase in the number of skin cells in skin tissue exposed
to the laser can improve the human skin immune system to help improve human body response to
vaccines.
non-painful and non-damaging dose to changes the skin properties.The researcher can prove
that signaling and a significant increase in the number of skin cells in skin tissue exposed
to the laser can improve the human skin immune system to help improve human body response to
vaccines.
The researcher can use low power laser light one-minute exposures delivered to the skin at
non-painful and non-damaging dose. The resulted in significant immunologic changes in the
skin that included up-regulation of specific skin tissue and skin genes and the activation
and mobilization of specific skin cells.
In the first part of the study, the researcher will make a determination of the laser
irradiance that will be tolerated. The highest irradiance the subject tolerates for 1 minute
will be identified as that subject's maximum tolerable irradiance. After all subjects are
tested, researcher will select the highest irradiance that was tolerated and use this in the
second phase of the study.
Approximately 24 hours after the first test exposures, each subject will receive a one minute
laser treatment at the maximum tolerable irradiance. Four hours later, two skin biopsies will
be collected from laser treated site a untreated.
One tissue sample will be test at UC Irvine Dept. of Dermatopathology to evaluate microscopic
skin changes, one skin sample will be delivered to Massachusetts General Hospital to evaluate
RNA and protein expression.
non-painful and non-damaging dose. The resulted in significant immunologic changes in the
skin that included up-regulation of specific skin tissue and skin genes and the activation
and mobilization of specific skin cells.
In the first part of the study, the researcher will make a determination of the laser
irradiance that will be tolerated. The highest irradiance the subject tolerates for 1 minute
will be identified as that subject's maximum tolerable irradiance. After all subjects are
tested, researcher will select the highest irradiance that was tolerated and use this in the
second phase of the study.
Approximately 24 hours after the first test exposures, each subject will receive a one minute
laser treatment at the maximum tolerable irradiance. Four hours later, two skin biopsies will
be collected from laser treated site a untreated.
One tissue sample will be test at UC Irvine Dept. of Dermatopathology to evaluate microscopic
skin changes, one skin sample will be delivered to Massachusetts General Hospital to evaluate
RNA and protein expression.
Inclusion Criteria:
- Adult men and women with skin type 1 and 2
- Not pregnant
Exclusion Criteria:
- Use of systemic steroids, topical steroids, tanning solutions and anticoagulant
- History of HIV, mentally incompetent, prisoner, alcohol or drug impairment
- Abnormal photosensitivity
We found this trial at
2
sites
Irvine, California 92612
Principal Investigator: Kristen Kelly, MD
Phone: 949-233-9060
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Charlestown, Massachusetts 02129
Phone: 617-726-1796
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