Fibrostenotic Eosinophilic Esophagitis: Assessment Tools
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 5 - 18 |
| Updated: | 2/10/2019 |
| Start Date: | December 2014 |
| End Date: | June 2019 |
| Contact: | Faria Ahmed |
| Email: | faria.ahmed@childrenscolorado.org |
| Phone: | 720-777-2797 |
Fibrostenotic Eosinophilic Esophagitis: Endoscopic, Histologic and Molecular Characterization and Evaluation of Clinical Assessment Tools
This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis
(EoE) is characterized by abnormal esophageal structure and compliance compared to non
fibrostenotic EoE and that distinctive cellular and molecular profiles predict the
fibrostenotic phenotype. This study aims to define and assess the changes that occur in the
structure and dynamics of the esophageal wall in pediatric Eosinophilic Esophagitis along
with characterizing the histologic and molecular patterns in fibrostenotic EoE.
(EoE) is characterized by abnormal esophageal structure and compliance compared to non
fibrostenotic EoE and that distinctive cellular and molecular profiles predict the
fibrostenotic phenotype. This study aims to define and assess the changes that occur in the
structure and dynamics of the esophageal wall in pediatric Eosinophilic Esophagitis along
with characterizing the histologic and molecular patterns in fibrostenotic EoE.
Inclusion Criteria:
- Scheduled to undergo a clinical upper endoscopy with biopsy
Exclusion Criteria:
- Known connective tissue disorder
- Increased risk of bleeding
- Inflammatory bowel disease, celiac disease, eosinophilic gastroenteritis, or any
autoimmune disease
- Other esophageal disease including known achalasia; history of caustic ingestion,
esophageal surgery esophageal stricture for other known reason or other esophageal
injury.
- Use of oral or intravenous steroids in the preceding 60 days. (Swallowed topical
fluticasone, budesonide, etc not included as exclusion criteria.)
We found this trial at
1
site
13123 E 16th Ave
Aurora, Colorado 80045
Aurora, Colorado 80045
(720) 777-1234
Phone: 720-777-2797
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