Novel Pharmacotherapy for Dual Dependence

Our objective is to understand the basic mechanisms that underpin substance dependence, and
to develop efficacious treatments for individuals with comorbid cocaine and alcohol
dependence.

Participants in this study will be randomly assigned to receive either 300 mg per day of
topiramate or placebo. In addition, participants will receive weekly cognitive behavioral
therapy for 12 weeks.Follow-up visits will occur at 2 weeks and 1,2,, and 3 months following
completion of treatment.

Inclusion Criteria:

- Subjects will be men and women between the ages of 18 years and older.

- Must meet at least three of the seven DSM IV diagnostic criteria for alcohol and
cocaine dependence.

- Express a desire for treatment.

- Literacy in English and ability to read, understand, and complete the ratings scales
and questionnaires accurately, follow instructions, and make use of the behavioral
treatments are required.

- Prospective subjects must report cocaine use of at least once per month and alcohol
consumption of ≥21 drinks/week and ≥14 drinks/week for men and women respectively,
during the past 30 days

- At least one positive urine drug screen for cocaine at screen or baseline prior to
randomization.

Exclusion Criteria:

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