Early Indicators of Chronic Rejection in Lung Transplant

Lung transplant recipients are routinely followed in clinic every three months after the
first year post-transplant. Spirometry with measurement of FEV1, FVC and FEF25-75 are
obtained at each visit. In addition, lung transplant recipients undergo surveillance
bronchoscopy at one, three, six, nine and twelve months. All bronchoscopy specimens that are
obtained for this study will be obtained during bronchoscopies that were scheduled per the
physician caring for the patient. An extra 90 cc of sterile solution will be instilled into
bronchus and two extra transbronchial biopsies will be performed in addition to the routine
bronchoscopic procedure. Routinely, 4-8 transbronchial biopsy samples are obtained from the
transplanted lung. Two specimens will be randomly selected for study and the rest will
undergo routine histopathologic study. The study biopsies will be set aside and processed.
The study visits for this research will occur at the same time as standard of care post
transplant visits. We will collect subject's history,demographic of subject's transplant
data,donor procurement information, physical exam information, pregnancy tests,blood test
and spirometry results from the visits mentioned above.

Inclusion Criteria:

- Lung transplant recipients between the ages of 18 and 65 years old

- All patients must be able to give written informed consent

Exclusion Criteria:

- Lung transplant recipients who are unable to undergo bronchoscopy

- Lung transplant recipients who are unable to give informed consent