Prospective Study to Determine Impact of Early Palliative Care Consult on Quality of Life (QOL), Cancer Related Symptoms In Advanced Lung Cancer Patients: Thoracic Pilot Project

Advanced lung cancer (ALC) will be assessed for participant outcomes in a sample which is
prior initiation of palliative consultation and in a sample after the initiation of early
palliative consultation.

Study goals are:

I. To determine the differences in participant outcomes including quality of life (QOL);
symptom distress [Edmonton symptom assessment scale (ESAS)] and caregiver outcomes [Zarit
Burden Interview {ZBI}, Hospital Anxiety and Depression scale(HADS) and FAMCARE] at week 12
in advanced lung cancer (ALC) patients receiving early palliative care consultation versus
those who don't.

II. Identify the cellular, molecular, and immune basis for the development of symptoms in
patients with ALC.

Inclusion Criteria:

1. Have a diagnoses of advanced NSCLC (defined as locally advanced or metastatic)

2. Have no clinical evidence of cognitive failure, as evidenced by a Memorial Delirium
Assessment Score of less than or equal to 7 of 30 at the time of consent.

3. Be at least 18 years of age.

4. Be able to understand the description of the project and give written informed
consent.

5. Plan to receive their cancer treatment at MD Anderson Cancer Center.

6. Individuals with advanced cancer who are able to identify a primary caregiver who also
agrees to participate (in person or by telephone) in the study. A caregiver will be
defined as a spouse, first degree relative, or other person designated by the patient
as providing direct assistance to the patient in his/her activities of daily living.

Exclusion Criteria:

1. Patients to be excluded from the study will be those unable to complete the baseline
assessment forms or to understand the recommendations for participation in this
project.

2. Patients seen at the Thoracic center at UT MD Anderson Cancer Center after 8 weeks of
the initial diagnosis (first cohort only - patients using the current Palliative Care
referral practices prior to the implementation of the early palliative care program).