Exercise Intervention for LGBT Cancer Survivors

The proposed randomized controlled trial aims to recruit 70 lesbian, gay, bisexual, and
transgender (LGBT) cancer survivors who have completed treatment (surgery, radiation, or
chemotherapy) within the past 24 months, so as to have a final, evaluable sample of 60 LGBT
survivors after attrition. The proposed RCT will also recruit caregivers (broadly defined) of
the above cancer survivors. Each recruited cancer survivor will be asked to name a person who
they feel provided care (emotional, informational, tangible, etc.) during their cancer
experience, with no further strictures placed on this relationship in terms of type or
duration. The caregiver will be approached to participate in the RCT. Thus the sample will
consist of 70 LGBT survivors (60 evaluable) and their caregivers (140 individuals total/120
evaluable). Recruitment and primary analyses will specifically target the LGBT cancer
survivor.

All data will be gathered from participants 21 years of age or older. Participants are cancer
survivors who have completed treatments or caregivers of cancer survivors; both survivors and
caregivers are able to read and understand English.

Inclusion Criteria:

- (Survivors): To be included in the study, cancer survivors must:

- Have had a diagnosis of cancer (any cancer type excluding squamous and basal cell
[skin cancers]) and have completed primary surgery, chemotherapy, and/or radiation
(those on continued adjuvant treatment are still eligible),

- Identify as lesbian, gay, bisexual, or transgender, or have a same-sex romantic
partner,

- Have a caregiver willing to participate in the study (defined as anyone who provided
emotional support or tangible assistance during the survivors' cancer experience),

- Be able to read English,

- Be 21 years of age or older, and

- Give written informed consent.

- (Caregivers): Caregivers must:

- Be nominated by a cancer survivor,

- Be able to read English,

- Be 21 years of age or older,

- Give written informed consent.

Exclusion Criteria:

- Have physical limitations (e.g., cardiorespiratory, orthopedic) contraindicating
participating in a low- to moderate-intensity home-based walking and progressive
resistance program and physical function testing, as assessed by their medical
oncologist, their primary care physician, and/or the study medical monitor (or any of
these three physicians' designees),

- For caregivers, be currently undergoing active treatment for cancer.