Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke

Subcortical strokes affect small vessels deep in the brain, and typically present with motor
hemiparesis. The investigator will assess the effects of Transcranial Magnetic Stimulation
(TMS) on motor function and examine how different areas in the human brain interact with each
other using brain imaging and brain stimulation. The investigator will also evaluate the
capacity for noninvasive stimulation to transiently modify brain activity supporting arm
movement.

Inclusion Criteria:

1. Age between 18-85 years

2. Middle cerebral artery stroke

3. Individuals with a first time stroke that affects the corona radiata and/or internal
capsule

Exclusion Criteria:

1. Age outside the age range of 18-85 years

2. Signs of dementia (score < 24 on the Montreal Cognitive Assessment)

3. Aphasia (score < 13 on the Frenchay Aphasia Screen)

4. History of head trauma

5. History of a major psychiatric diagnosis

6. History of a neurodegenerative disorder

7. History of substance abuse

8. Contraindications to Transcranial Magnetic Stimulation