Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)

The purpose of this study is to investigate arm and hand function after stroke and how the
location of the brain lesion affects arm and hand function. We are hoping to collect data in
the form of assessments what you feel and how your arm moves, surveys about activities in
daily life and well-being, and we will perform 1 Magnetic Resonance Imaging (MRI) scan. MRI
scans are loud but painless; nothing is injected. With MRI, we collect images from the brain.

Inclusion Criteria:

- Inclusion criteria for healthy subjects are:

- medically stable;

- 18 - 99 years of age;

- able to hear the instructions given during the study

Inclusion criteria for stroke patients are:

- at least 6 months post-stroke;

- medically stable;

- 18 - 99 years of age;

- subcortical or cortical infarct confirmed with MRI;

- Mini-mental State Exam > 24/30 (Folstein et al., 1975);

- able to hear the instructions given during the study;

- able to comprehend the instructions given during the study;

- able to commit time to participate in a 6-12-weeks rehabilitation program

Exclusion Criteria:

Exclusion criteria for healthy subjects are:

- having ever experienced a stroke or another brain injury or illness related to the
brain that has lasting effects or effects experienced at the moment of recruitment;

- severe sensory impairments such that different movements of the finger, hand or wrist
are not reliably felt;

- contractures in tested arm that hinder persons from keeping the outstretched arm in a
relaxed position;

- interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);

- exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal
parts in the body etc);

- pregnant or nursing mother;

- adults lacking capacity to consent

Exclusion criteria for stroke patients are:

- insular or cerebellar infarcts/brain lesions;

- unilateral spatial neglect, identified by a standard neuropsychological assessment
(Bell's test (score/35, Gauthier et al., 1989);

- aphasia;

- apraxia (TULIA, Vanbellingen et al., 2011);

- severe sensory impairments such that different movements of the finger, hand or wrist
are not reliably felt;

- contractures in the hemiplegic arm that hinder patients from keeping the outstretched
arm in a relaxed position;

- interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);

- patients currently receiving therapy for their hemiplegic arm, the latter in order to
avoid confounding treatment effects;

- exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal
parts in the body etc);

- pregnant or nursing mother;

- adults lacking capacity to consent