Gentle Yoga and Dietary Counseling in Improving Physical Function and Quality of Life in Stage I-II Endometrial Cancer Survivors

PRIMARY OBJECTIVES:

I. To determine the feasibility and efficacy of a combined lifestyle intervention (yoga +
diet) to positively impact physical function and quality of life for endometrial cancer
survivors.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Participants undergo onsite gentle yoga once weekly over 45-60 minutes for 8 weeks
and home-based gentle yoga for 6 weeks. Participants also undergo dietary counseling over 8
weeks.

ARM II: Participants undergo enhanced usual care designed to educate on best practices for
exercise, diet and lifestyle change once weekly for 14 weeks.

Inclusion Criteria:

- English speaking

- Previous diagnosis of grade 1 or 2, stage I or II endometrioid endometrial cancers
("type I cancers") as confirmed during surgical intervention for treatment

- Overweight or obese (> 25 kg/m^2)

- Anytime from treatment

- Treating oncologist consent

- Primary physician consent to engage in physical activity unsupervised

- Ambulatory or able to engage in walking for at least 15 minutes

- Sedentary lifestyle, as engaging in less than 100 minutes structured aerobic walking,
cycling or swimming per week

Exclusion Criteria:

- No prior type I endometrial cancer diagnosis

- Prior diagnosis of other cancer

- Currently (previous 6 months) engaged in structured exercise either aerobic or yoga
based

- Severe heart or systemic disease: evidence of documented myocardial infarction,
chronic unstable angina, symptomatic congestive heart failure, uncontrolled
hypertension

- Severe musculoskeletal disease: severe muscle or joint disorders due to disease or
trauma, amputations, or any condition that significantly impair physical
capabilities, as defined by the physician

- Non-ambulatory

- Concurrent diagnosis of organic brain syndrome, dementia, mental retardation, or
significant sensory deficit

- Major mental illness (e.g., schizophrenia, major depressive disorder)

- Unwilling to give consent