COMPASS Trial: a Direct Aspiration First Pass Technique

This is a prospective, randomized trial comparing mechanical thrombectomy with the ADAPT
approach to stent retrievers in patients presenting with AIS within 6 hours of symptom onset.
Any cleared mechanical stent retriever (SR) or aspiration catheter device that is in common
use in the operator's region of practice is approved for use. Prior to releasing any sites to
enroll patients, we will collect the following information on the most recent 20 acute
ischemic stroke cases, at least five of which must have used direct aspiration as a first
approach, and at least five of which must have used stent retrievers as a first approach. It
is permissible to go back in time farther than the most recent 20 cases to fulfill either or
both of these requirements. There is no requirement for the remaining 10 cases. The
datapoints to be collected include:

- Age

- Gender

- LVO location

- Side of LVO

- NIHSS at presentation

- Time of onset

- Time of hospital arrival

- Time imaging completed

- Time of groin puncture

- Time of revascularization, if applicable

- Time procedure terminated, if revascularization was not obtained

- tPA given pre-procedure

- Time of IV-tPA

- Imaging type

- Perfusion imaging

- Devices used

- Passes attempted

- Device success

- Standard and modified final TICI scores

- Outcome measurements: incidence of post-op ICH, discharge and 90 day NIHSS, discharge
and 90 day mRS, any and all complications Patients who meet the inclusion and exclusion
criteria, consent to participate, and who are randomized will be considered enrolled.
Treatment arm will be randomly assigned by a central web-based system in a 1:1 manner to
treatment with either ADAPT or SR thrombectomy. Data on each patient will be collected
at the time of enrollment and treatment, and at subsequent follow-up visits.

Inclusion Criteria:

1. Age 18 and older (i.e., candidates must have had their 18th birthday)

2. NIHSS ≥8 at the time of neuroimaging

3. Presenting or persistent symptoms within 6 hours of when groin puncture can be
obtained

4. Neuroimaging demonstrates large vessel proximal occlusion (distal ICA through MCA
bifurcation)

5. The operator feels that the stroke can be appropriately treated with traditional
endovascular approaches (the ADAPT approach or conventional first-line stent retriever
approach)

6. Pre-event Modified Rankin Scale score 0-1

7. Non-contrast CT/CTA for trial eligibility performed or repeated at treating ADAPT
stroke center.

8. Consenting requirements met according to local IRB

Exclusion Criteria:

1. Patient is more than 6-hours from symptom onset

2. Rapidly improving neurologic examination

3. Absence of large vessel occlusion on non-invasive imaging

4. Presence of an existing or pre-existing large territory infarction

5. Known or suspected pre-existing (chronic) large vessel occlusion in the symptomatic
territory

6. Absent femoral pulses

7. Excessive vascular access tortuosity that will likely result in unstable access
platform.

8. Pregnancy; if a woman is of child-bearing potential a urine or serum beta HCG test is
positive.

9. Severe contrast allergy or absolute contraindication to iodinated contrast.

10. Clinical history, past imaging or clinical judgment suggests that the intracranial
occlusion is chronic.

11. Patient has a severe or fatal comorbidities that will likely prevent improvement or
follow-up or that will render the procedure unlikely to benefit the patient.

Head CT or MRI Scan Exclusion Criteria

- Presence of blood on imaging (subarachnoid hemorrhage (SAH)), intracerebral hemorrhage
(ICH), etc.)

- High density lesion consistent with hemorrhage of any degree

- Significant mass effect with midline shift

- Core infarct lesion volume >50 cc.

- Large (more than 1/3 of the middle cerebral artery) regions of clear hypodensity on
the baseline CT scan or ASPECTS of < 7; Sulcal effacement and/or loss of grey-white
differentiation alone are not contraindications for treatment.