Study of HUCNS-SC Subretinal Transplantation in Subjects With GA of AMD

A fellow eye controlled study of HUCNS-SC sub-retinal transplantation in subjects with
bilateral geographic atrophy (GA) age-related macular degeneration (AMD). All subjects will
be assigned to HUCNS-SC transplantation. All subjects will be followed for efficacy and
safety for 12 months. An independent data monitoring committee (IDMC) will review adverse
events for the duration of the study.

Inclusion Criteria:

- GA associated with AMD in both eyes. Total area of GA determined by fundus
autofluorescence.

- BCVA of 20/320 or better in each eye at screening assessment

Exclusion Criteria:

- Prior or concurrent choroidal neovascularization in either eye by clinical exam
and/or fluorescein angiography as determined by the investigator or the reading
center.

- Retinal or macular disease of any other cause in either eye.

- Diagnosis of glaucoma in either eye.

- Uncontrolled intraocular pressure in either eye

- Compromised renal function defined as eGFR <60mL/min and urine protein-to-creatinine
ration >0.3 is spot urine collection.

- History of or active autoimmune disease.

- Previous organ, tissue or bone marrow transplantation.

- Seropositive for HIV, hepatitis B or C, or CMV IgM