Web-based Lifestyle Trial Among Men With Prostate Cancer: Prostate 8

This is a PI-initiated, randomized, unblinded, clinical trial of a technology-based 3 month
lifestyle intervention vs. usual care among men with low risk prostate cancer. We will
recruit and consent 76 men with prostate cancer at UCSF. The subjects will be asked to
complete questionnaires, 7 days accelerometer measurement, body measurements (weight, waist,
hip, pulse, blood pressure) and collection of blood specimen at baseline and 3 months.
Subjects will be randomized into two arms (Intervention Group and Control Group). The
Intervention Group (N=38) will have access to the lifestyle website and an activity monitor
(e.g., Fitbit), receive text messages, and be provided with individualized lifestyle
recommendations. The Control Group (N=38) will have standard of care and be asked to continue
with their usual lifestyle habits. They will receive access to the lifestyle website and be
provided with individualized lifestyle recommendations at 3 months.

Inclusion Criteria:

1. clinical stage ≤T3a nonmetastatic prostate cancer within 5 years

2. completion of treatment ≥3 months prior to enrollment, if not on active surveillance

3. ability to walk unassisted

4. be able to speak and read English

5. ability to navigate websites and email, and have internet access

6. able to travel to UCSF for pre- and post-study blood collection

Exclusion Criteria:

1. any contraindications to moderate or vigorous aerobic exercise

2. psychiatric condition preventing the patient from giving informed consent or adhering
to the study protocol

3. reporting adherence to more than 4 of the 8 targeted lifestyle behaviors via
questionnaires at screening