Exparel for Postoperative Pain Management in Shoulder Surgery

liposomal bupivacaine analgesia will provide improved postoperative pain control, reduction
in amount of opioid supplementation, decreased complications and faster return to function
compared to current standard of care pain management for patients undergoing shoulder
arthroplasty and shoulder surgery for proximal humerus fractures.

Inclusion Criteria:

- Patients undergoing shoulder arthroplasty under general anesthesia

- Patients undergoing open reduction internal fixation (ORIF) of a proximal humerus
fracture under general anesthesia

- Patients with American Society of Anesthesiologist (ASA) physical status
classification of 1-3

- Patients meeting criteria for standard of care continuous peripheral nerve block
(CPNB) per anesthesia guidelines.

- Patients agreeing to be available for brief follow up telephone survey post-
operatively and being mentally able to respond.

- Patients available for follow up routine post-operative clinic visits, per standard
of care.

Exclusion Criteria:

- Contraindications to regional anesthesia

- Significant peripheral neuropathy or neurological disorder affecting the upper
extremity

- Contraindication to a component of multimodal analgesia

- Pregnancy

- Opioid tolerance

- Cognitive or psychiatric condition that might affect patient assessment and/or
inability to provide informed consent.