Familial Intracranial Aneurysm Study II

Intracranial aneurysms are "blisters" which form within the arteries at the base of the
brain. A rupture of an aneurysm may lead to subarachnoid hemorrhage (SAH). The mortality
rates of patients suffering from a SAH is 40 to 44 percent , with many survivors enduring
major disability. Most of the deaths from SAH are due to rapid and massive brain injury from
the initial bleeding, which is not correctable by medical and surgical intervention. Thus,
prevention of aneurysm formation is of paramount importance.

Scientific evidence suggests that a genetic component plays an important role in the
development of intracranial aneurysms, however the specific genes have not been identified.
The Familial Intracranial Aneurysm Study is a collaborative research effort of neurologists
and neurosurgeons throughout the United States, Canada, Australia and New Zealand to
identify possible genes that may increase the risk of stroke, and particularly, the
development of aneurysms in the blood vessels of the brain. This study will involve 475
families with multiple affected family members, and will also determine the effect of
environmental factors such as cigarette smoking and high blood pressure on the expression of
the genes.A group of physicians from throughout North America, Australia and New Zealand
have formed a collaborative effect to identify genes that may be important in the
development of aneurysms in the blood vessels of the brain. This study of affected
individuals and families, known as the Familial Intracranial Aneurysm (FIA) study, is
sponsored by the National Institutes of Health and has involved over 475 families.

FIA II will involve an additional 200 families plus 1800 subjects with an Intracranial
Aneurysm but no family history. These families and individuals will be used to replicate the
findings of FIA I. FIA II will take place in North America only.

To be eligible to participate in this study, families must have two or more affected pairs
of siblings (brothers/sisters) or 3 or more family members affected with intracranial
aneurysms. Subjects can participate if they do not have an eligible family history, but do
have a confirmed intracranial aneurysm.

Participants will be asked to complete a family history questionnaire (if they have a family
history) and a medical history questionnaire. They will also have their blood pressure
measured and will give a small sample of blood. In addition, medical records will be
requested to confirm the diagnosis of intracranial aneurysms. There will be no monetary
compensation for participation.

The identification of susceptibility genes, along with a better understanding of
environmental interactions such as cigarette smoking, may result in preventing the
development of intracranial aneurysms and/or intracranial aneurysm ruptures in people who
are at risk for this condition.

Inclusion:

- To be eligible to participate in this study, families must have two or more affected
pairs of siblings (brothers/sisters) or 3 or more family members affected with
intracerebral aneurysms.

Sporadic aneurysm subjects must have a confirmed aneurysm.

Exclusion:

- A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or
fibromuscular dysplasia.