FDG-PET/CT Imaging as Early Predictor of DP



Status:Completed
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/22/2019
Start Date:August 2014
End Date:August 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Pilot Study Using FDG-PET/CT Imaging as an Early Predictor of Disease Response in Lymphoma Subjects Receiving Redirected Autologous CART- 19 T-cell Immunotherapy

In this study the investigators would like to describe FDG-PET/CT responses in patients who
are receiving CART-19 immunotherapy for Follicular Lymphoma (FL), Diffuse Large B-cell
Lymphoma (DLBCL), and Mantle Cell Lymphoma (MCL) as part of UPCC #13413. Subjects will
undergo two FDG-PET/CTs. One performed within 6 weeks of CART-19 infusion and a repeat scan
at about 1 month after infusion.


Inclusion Criteria:

- Subjects enrolled on the study UPCC 13413 Pilot Study Of Redirected Autologous T Cells
Engineered To Contain Anti-Cd19 Attached To Tcr And 4-1bb Signaling Domains In
Patients With Chemotherapy Resistant Or Refractory Cd19+ Lymphoma CART-19 autologous
T-cell trial with relapsed or refractory DLBCL and FL. As this is a pilot study, we
plan to enroll 4 subjects from the two disease types of interest.

- Subjects ≥ 18 years of age

- Subjects able to provide informed consent and agree to comply with study
procedures

Exclusion Criteria:

- Subjects who are pregnant or lactating.

- Subjects will be co-enrolled in this study and UPCC 13413 and therefore must comply
with the UPCC 13413 Pilot Study Of Redirected Autologous T Cells Engineered To Contain
Anti-Cd19 Attached To Tcr And 4-1bb Signaling Domains In Patients With Chemotherapy
Resistant Or Refractory Cd19+ Lymphoma requirements pertaining to pregnancy,
lactation, conception and contraception use throughout their participation in both
studies.
We found this trial at
1
site
Abramson Cancer Center of the University of Pennsylvania
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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Philadelphia, PA
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