Screening for PDAC in BRCA1/2 Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/27/2019 |
| Start Date: | May 2015 |
| End Date: | May 2023 |
| Contact: | Anil Rustgi, MD |
| Email: | PennCancerTrials@emergingmed.com |
| Phone: | 855-216-0098 |
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With BRCA1/2 Mutations
The study is a prospective, observational, case-control study evaluating the utility of
endoscopic ultrasound for the identification of preneoplastic and neoplastic pancreatic
lesions in patients at high risk for pancreatic cancer, specifically those with BRCA1/2
mutations.
endoscopic ultrasound for the identification of preneoplastic and neoplastic pancreatic
lesions in patients at high risk for pancreatic cancer, specifically those with BRCA1/2
mutations.
Inclusion Criteria:
- Informed consent provided
- Age greater than or equal to 18
Patients:
- Able and willing to attend routine follow-up as advised BRCA2 Mutation Carriers
- Patients with a history of BRCA2 Mutation, with or without manifestation of breast or
ovarian cancer, over the age of 50.
- Any BRCA2 patient who has a first degree or 2 second degree family members with a
history or pancreatic cancer will initiate screening 10 years prior to the age of
onset of the index pancreatic neoplasia. BRCA1, ATM, & PALB2 Mutation Carriers
- Any BRCA1 patient who has a first degree or 2 second degree family members with a
history or pancreatic cancer will initiate screening 10 years prior to the age of
onset of the index pancreatic neoplasia.
Exclusion Criteria:
- Known infection with HIV, HBC, or HCV
- Pregnancy Esophageal strictures prior to treatment
- Zenkers Diverticulum prior to treatment
- History of abnormal or post surgical (i.e. post-Roux-en-Y Gastric Bypass) foregut
anatomy precluding endoscopic ultrasound examination of the pancreas.
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Principal Investigator: Anil Rustgi, MD
Phone: 855-216-0098
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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