NAC Trial for Anosmia
| Status: | Completed |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | July 2014 |
| End Date: | December 1, 2017 |
Pilot Study of Topical Intranasal N-acetyl Cysteine Administration for the Treatment of Anosmia
The purpose of this research study is to evaluate the use of NAC in the treatment of anosmia
(a loss of the sense of smell). This drug is already approved by the Food and Drug
Administration (FDA) for oral or pulmonary (lung) inhaled use for other medical conditions.
However, there is research evidence that the medication may promote nerve recovery (help
nerves work better after they are damaged). Since anosmia involves nerve problems, we believe
the nasal spray may help treat anosmia. The medication has been in use for many years for
other conditions, without safety problems.
(a loss of the sense of smell). This drug is already approved by the Food and Drug
Administration (FDA) for oral or pulmonary (lung) inhaled use for other medical conditions.
However, there is research evidence that the medication may promote nerve recovery (help
nerves work better after they are damaged). Since anosmia involves nerve problems, we believe
the nasal spray may help treat anosmia. The medication has been in use for many years for
other conditions, without safety problems.
Inclusion Criteria:
- adults at least 18 years of age with documented microsmia or anosmia by University of
Pennsylvania Smell Identification Test.
- patients must have no evidence of active sinonasal disease by nasal endoscopy or CT or
MRI
- negative CT or MRI
Exclusion Criteria:
- adults unable to consent
- individuals who are not yet adults (infants, children, teenagers)
- pregnant women, prisoners, employees or subordinates,
- patients with known sensitivity to NAC or severe asthma
- patients with sinus or central disease on CT or MRI imaging.
We found this trial at
1
site
Miami, Florida 33136
Principal Investigator: Bradley J Goldstein, MD, PhD
Phone: 305-243-7102
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