Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/5/2017 |
| Start Date: | June 2015 |
| End Date: | March 2018 |
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term
increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function
and increase the risk of CVD. Greater intakes of dairy foods have been associated with a
lower risk of CVD, but whether these effects occur directly or indirectly by displacing
foods in the diet that might increase CVD risk is unclear. The health benefits of dairy on
heart health are at least partly attributed to its ability to limit PPH and resulting
PPH-mediated responses leading to vascular dysfunction. This provides rationale to further
investigate dairy as a dietary strategy to reduce PPH and risk for CVD. The objective of
this study is to define the extent to which dairy milk, and its whey and casein protein
fractions, protect against postprandial vascular dysfunction by reducing oxidative stress
responses that limit nitric oxide bioavailability to the vascular endothelium in adults with
prediabetes.
increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function
and increase the risk of CVD. Greater intakes of dairy foods have been associated with a
lower risk of CVD, but whether these effects occur directly or indirectly by displacing
foods in the diet that might increase CVD risk is unclear. The health benefits of dairy on
heart health are at least partly attributed to its ability to limit PPH and resulting
PPH-mediated responses leading to vascular dysfunction. This provides rationale to further
investigate dairy as a dietary strategy to reduce PPH and risk for CVD. The objective of
this study is to define the extent to which dairy milk, and its whey and casein protein
fractions, protect against postprandial vascular dysfunction by reducing oxidative stress
responses that limit nitric oxide bioavailability to the vascular endothelium in adults with
prediabetes.
This study consists of four, 3-hour postprandial trials in response to consuming the
following dietary treatments: 1. oral glucose challenge, 2. oral glucose challenge in
combination with non-fat milk, 3. oral glucose challenge in combination with whey protein
isolate, and 4. oral glucose challenge in combination with sodium caseinate. For three days
preceding each trial, participants will be provided all meals to standardize physiologic
responses to test meals. On each trial day, vascular function will be assessed and blood
samples collected prior to and at 30 minute intervals for 3 hours following test meal
ingestion.
following dietary treatments: 1. oral glucose challenge, 2. oral glucose challenge in
combination with non-fat milk, 3. oral glucose challenge in combination with whey protein
isolate, and 4. oral glucose challenge in combination with sodium caseinate. For three days
preceding each trial, participants will be provided all meals to standardize physiologic
responses to test meals. On each trial day, vascular function will be assessed and blood
samples collected prior to and at 30 minute intervals for 3 hours following test meal
ingestion.
Inclusion Criteria:
1. hemoglobin A1c 5.7-6.4%
2. non-dietary supplement user
3. no medications affecting vasodilation, inflammation, or energy metabolism
4. no CVD
5. nonsmokers
6. individuals having blood pressure <140/90 mmHg and total cholesterol <240 mg/dL
Exclusion Criteria:
1. unstable weight (±2 kg)
2. vegetarian or dairy allergy
3. alcohol intake >3 drinks/day or >10 drinks/week
4. ≥7 hours/week of aerobic activity
We found this trial at
1
site
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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