Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
| Status: | Completed |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/7/2018 |
| Start Date: | March 17, 2015 |
| End Date: | July 27, 2017 |
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative
pain after scheduled, elective Cesarean delivery. All patients will receive a standardized
spinal anesthetic for operative anesthesia and will be randomized into one of three groups:
(group 1) 1 gram IV acetaminophen every 8 hours for three doses, (group 2) 1 gram oral
acetaminophen every 8 hours for three doses, or (group 3) no acetaminophen. This will be a
randomized, open label study.
pain after scheduled, elective Cesarean delivery. All patients will receive a standardized
spinal anesthetic for operative anesthesia and will be randomized into one of three groups:
(group 1) 1 gram IV acetaminophen every 8 hours for three doses, (group 2) 1 gram oral
acetaminophen every 8 hours for three doses, or (group 3) no acetaminophen. This will be a
randomized, open label study.
This study will compare IV versus PO acetaminophen for postoperative pain in parturients
after scheduled, elective Cesarean delivery. It is designed as a randomized, open label,
controlled trial. All patients will receive a standardized spinal anesthetic for operative
anesthesia and will be randomized into one of three groups: (group 1) 1 gram IV acetaminophen
every 8 hours for three by a computer generated list.
after scheduled, elective Cesarean delivery. It is designed as a randomized, open label,
controlled trial. All patients will receive a standardized spinal anesthetic for operative
anesthesia and will be randomized into one of three groups: (group 1) 1 gram IV acetaminophen
every 8 hours for three by a computer generated list.
Inclusion Criteria:
- Parturients 18 years
- Elective Cesarean delivery
- Spinal anesthesia
- Able to consent to the study and participate in the follow-up.
Exclusion Criteria:
- Weight under 50 kgs
- Allergy to acetaminophen
- General anesthesia
- Urgent or emergent cases
- Bleeding diathesis or other coagulopathy
- G6PD deficiency
- Liver disease
- Substance abuse or dependence
- HELLP syndrome
- Thrombocytopenia or platelet dysfunction
- History or active gastrointestinal bleeding
- Acute kidney injury or chronic renal insufficiency
- Contraindication/refusal to spinal anesthesia
- Chronic pain
- Chronic narcotic use
- Illicit drug use
- Allergy to any study related medications.
We found this trial at
1
site
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Sylvia H Wilson, MD
Phone: 843-792-1869
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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