Training Attentional Awareness and Control in ADHD

Different types of software-based cognitive training are thought to impact attention via
different mechanisms. This study examines the nature of the effects on sustained attention
of two different types of mobile software based training. Because the nature of the training
method is behavioral, the investigators can not divulge the differences in the training
methods and their hypothesized differences in their impact on attention.

Inclusion Criteria:

1. Meet established DSM-5 criteria for ADHD predominately inattentive or combined
subtype with clinically significant levels of impairment, diagnosed by structured
clinical interview, the Mini International Neuropsychiatric Interview, and
corroborating information

2. Clinical Global Impression—Severity (CGI-S) score ≥ 4 for ADHD

3. No lifetime history of DSM-5 bipolar disorder, psychotic disorder, pervasive
developmental disorder, obsessive-compulsive disorder, substance abuse, or substance
dependence (except nicotine) as assessed wit the MINI

4. Able in the opinion of the investigator to complete all required study procedures.

Exclusion Criteria:

1. History of diagnosis of childhood disorder other than ADHD (e.g. autism, dyslexia)

2. History of any general medical condition likely to require chronic use of medication
with identified CNS effects suspected to alter cognitive performance

3. History of seizure disorder, brain tumor, other major neurological disorder or head
injury resulting in loss of consciousness

4. Serious oxygen deprivation

5. Current psychopathology requiring ongoing treatment with antipsychotic medications,
mood stabilizers, benzodiazepines, or anticonvulsants

6. Current untreated psychopathology which is rated to be primary in terms of severity
(greater than ADHD severity)

7. Current treatment with guanfacine.