First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement

Key Inclusion Criteria:

- Male and female patients age 50 to 75 years of age inclusive, and in good health as
determined by past medical history, physical examination, vital signs,
electrocardiogram, and laboratory tests at screening

- Patients diagnosed with primary osteoarthritis of the knee assessed locally for whom a
total knee replacement is planned

- General health status acceptable for total knee replacement surgery in the opinion of
the investigator

- Stable medications within 3 months prior to enrollment (such as appropriate pain
medication, antibiotics prophylaxis) and standard of care

Key Exclusion Criteria:

- Presence of inflammatory arthropathy (including but not limited to rheumatoid
arthritis, psoriatic arthritis, ankylosing spondylitis, gout), active acute or chronic
infection, or systemic cartilage disorder

- Prior cartilage repair surgery, e.g. microfracture, autologous cartilage implantation
(ACI) or else, at the same knee

- Any surgical therapy or local treatment i.a. into the knee (viscosupplementation) to
the knee within 2 months prior to enrollment

- BMI > 40; presence of uncontrolled diabetes or hyperthyroidism

- Large effusion in the knee to be replaced, more than (>)1 cm fluid in the
suprapatellar space at the midline

- Corticosteroid use by any route except topical and nasal in the 3 months prior to
enrollment

- History of malignancy of any organ system (other than localized basal cell carcinoma
of the skin or in-situ cervical cancer), treated or untreated, within the past 5
years, regardless of whether there is evidence of local recurrence or metastases

- Pregnant or nursing (lactating) women

- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant