A Multicenter, Multinational, Observational Morquio A Registry Study (MARS)

MARS is a multicenter, multinational, observational disease registry for patients diagnosed
with Mucopolysaccharidosis Type IVA (MPS IVA). The Registry will collect medical history, and
clinical and safety assessments every six months, for up to 10 years. The Registry will
enroll and collect data on patients over a period of at least 8 years from the time of the
first marketing approval globally and data on individual patients will continue to be
collected for at least 2 years from the time the last patient was enrolled or until the
Registry is completed.

These assessments are designed to further characterize the spectrum of clinical signs and
symptoms of the disease, and to further characterize the safety profile of Vimizim in a
broader population. It is not required that patients receive Vimizim to be eligible to
participate in this Registry.

In addition, this Registry will collect additional data on patients who have completed the
MOR-005 and MOR-007 clinical trials. The MOR-005 and MOR-007 clinical trial patients will be
enrolled into the appropriate Registry Substudy for a minimum of 5 years from the time of the
patient's enrollment in the MOR-005 clinical study or MOR-007 clinical study. After the 5
year period, these patients should remain in MARS until the Registry is complete.

Inclusion Criteria:

Patients eligible to participate in this Registry must meet all of the following criteria:

- Diagnosed with MPS IVA as confirmed by either N-acetylgalactosamine 6-sulfatase
(GALNS) enzymatic test or by a diagnostic molecular test

- Willing and able to provide written, signed informed consent, or, in the case of
patients age < 18 years, provide written assent (if required) and written informed
consent, signed by a legally authorized representative after the nature of the
Registry has been explained and prior to performance of any Registry-related
procedures

- Willing to undergo assessments to establish baseline data or permit Investigator to
enter assessment data recorded prior to Registry entry if available in the patient's
medical records. Entry assessments may include: demographics, medical history, urinary
keratan sulfate level, urinary protein level, immunogenicity testing, vital signs,
physical examination, and height and weight

Patients eligible to participate in the Registry Substudy for MOR-005 must meet all of the
following criteria:

- Must have completed the MOR-005 clinical trial

- Willing and able to provide written, signed informed consent, or, in the case of
patients age < 18 years, provide written assent (if required) and written informed
consent by a legally authorized representative after the nature of the Registry
Substudy has been explained and prior to any Registry-related Substudy procedures

- Willing to permit Investigator to enter assessment data recorded prior to Registry

- Substudy entry if available in the patient's medical records

Patients eligible to participate in this Registry Substudy for MOR-007 must meet all of the
following criteria:

- Must have completed the MOR-007 clinical trial

- Willing and able to provide written, signed informed consent, or in the case of
patients age < 18 years, provide written assent (if required) and written informed
consent by a legally authorized representative after the nature of the Registry
Substudy has been explained, and prior to any Registry-related Substudy procedures

- Willing to permit Investigator to enter assessment data recorded prior to Registry
Substudy entry if available in the patient's medical records

Exclusion Criteria:

Patients who meet the following exclusion criterion will not be eligible to participate in
the Registry or Registry Substudies:

• Patients currently participating in a BMN 110 (elosulfase alfa) clinical trial