In Vitro Follicle Activation
| Status: | Terminated |
|---|---|
| Conditions: | Other Indications, Women's Studies, Infertility |
| Therapuetic Areas: | Other, Reproductive |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 8/31/2018 |
| Start Date: | July 2015 |
| End Date: | July 2017 |
In Vitro Activation of Primordial Follicles as a Method to Treat Infertility Caused by Primary Ovarian Insufficiency
The purpose of this study is to evaluate the effectiveness of an experimental treatment,
known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women
diagnosed with primary ovarian insufficiency (POI).
known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women
diagnosed with primary ovarian insufficiency (POI).
The purpose of this study is to evaluate the effectiveness of an experimental treatment,
known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women
diagnosed with primary ovarian insufficiency (POI; also known as premature ovarian failure).
Patients diagnosed with POI are infertile due to a lack of follicle growth and ovulation;
oocyte donation is the only treatment option currently available to enable these women to
have a child. IVA treatment may result in the rescue of the remaining primordial follicles
within the ovary, thus making oocytes available for IVF, embryo production, transfer and
pregnancy. In this experimental treatment, ovarian tissue is removed from the patient and
cultured in vitro for 48 hours with specific compounds to activate dormant primordial
follicles. Following activation ovarian tissue is auto-grafted to the serosa of the fallopian
tube, and the patient is monitored for signs of follicle growth. Growing follicles are
stimulated with exogenous hormones, followed by oocyte retrieval and IVF.
known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women
diagnosed with primary ovarian insufficiency (POI; also known as premature ovarian failure).
Patients diagnosed with POI are infertile due to a lack of follicle growth and ovulation;
oocyte donation is the only treatment option currently available to enable these women to
have a child. IVA treatment may result in the rescue of the remaining primordial follicles
within the ovary, thus making oocytes available for IVF, embryo production, transfer and
pregnancy. In this experimental treatment, ovarian tissue is removed from the patient and
cultured in vitro for 48 hours with specific compounds to activate dormant primordial
follicles. Following activation ovarian tissue is auto-grafted to the serosa of the fallopian
tube, and the patient is monitored for signs of follicle growth. Growing follicles are
stimulated with exogenous hormones, followed by oocyte retrieval and IVF.
Inclusion Criteria:
- Women diagnosed with primary ovarian insufficiency (POI), seeking pregnancy and
eligible for IVF at Colorado Center for Reproductive Medicine (Lone Tree, CO).
- Patients can be of any race, culture, sexual orientation or ethnicity.
Exclusion Criteria:
- Minors are excluded from participation in this study.
We found this trial at
2
sites
Click here to add this to my saved trials
Click here to add this to my saved trials