Pharmacogenetic Testing in an Outpatient Population of Patients With Depression

This is a randomized, control group design of pharmacogenetic implementation in a mental
health population of subjects taking anti-depressants and/or anti-psychotics with a new or
current primary or secondary diagnosis of Major Depressive Disorder (MDD) or Depressive
Disorder Not Otherwise Specified (DDNOS). Prospective data will be collected on all subjects
until study completion at 24-25 weeks post enrollment. Claims data may be reviewed per pay,
if such data are readily available in a timely manner.

Inclusion Criteria:

- Current primary or secondary diagnosis of Major Depressive Disorder or Depressive
Disorder Not Otherwise Specified

- Have moderate to severe depression as identified by PHQ-9 scoring of 10 or greater

- Taking or be newly prescribed an anti-depressant or anti-psychotic medication

- Able to provide informed consent

- Prescribing physician practices at the Avera Medical Group University Psychiatry
Associates clinic in Sioux Falls, SD

Exclusion Criteria:

- Pregnant or breastfeeding

- Active and/or unstable diagnosis of substance abuse, excluding nicotine

- Primary diagnosis of dementia, bipolar disorder (any type), schizophrenia,
schizoaffective disorder, or personality disorder