VG101 Phase I/II to Treat Vulvar and Vaginal Atrophy in Post-Menopausal Women

Primary Aims:

1. the optimal dose of VG101 based on the highest of 4 proposed dose levels that is not
associated with unacceptable toxicity during 12 weeks of treatment. Toxicity will be
based on National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events
(CTCAE), version 3. Unacceptable toxicity will be defined as the occurrence of any
Grade 3, 4, of 5 toxicity that is possibly or probably associated with study drug or
any other unacceptable toxicity as determined by the Data and Safety Monitoring Board.

2. Specific potential adverse effects of VG101

Secondary Aims:

1. the preliminary efficacy of VG101 to:

- relieve vulvar and/or vaginal dryness,

- relieve vulvar and/or vaginal irritation

- relieve vulvar and/or vaginal itching

- relieve vulvar and/or vaginal discharge

- relieve dyspareunia

- improve sexual function

- relieve dysuria

- reduce frequency of urinary incontinence

- improve quality of life

- improve the physical examination assessment of vaginal atrophy

- reduce vaginal fluid pH

- improve the proportion of superficial vaginal epithelial cells

2. participant adherence to VG101 administration

Inclusion Criteria:

1. Women between the ages of 45 and 65

2. Postmenopausal documented by: (a) at least one year of amenorrhea; (b) 6- 12 months
of amenorrhea with serum FSH > 40 IU/ml; (c) 6 weeks post-surgical bilateral
oophorectomy with or without hysterectomy, or (d) hysterectomy with serum FSH levels
> 40 IU/ml.

3. Self-report at least one moderate to severe symptom of vulvar or vaginal atrophy from
the following list:

- Vaginal dryness (none, mild, moderate or severe)

- Vaginal and/or vulvar discomfort (none, mild, moderate, severe)

- Vaginal and/or vulvar irritation (none, mild, moderate, severe)

- Vaginal itching (none, mild, moderate, severe)

- Vaginal pain associated with sexual activity (none, mild, moderate or severe)

4. < 5% superficial cells on vaginal cytologic smear.

5. Vaginal pH >5.0

6. Willing to use an intravaginal cream containing Chinese herbs for the treatment of
vaginal symptoms.

7. Provide informed consent.

Exclusion Criteria:

1. History of breast, uterine or ovarian cancer or melanoma.

2. Abnormal mammogram or breast examination within the last 9 months suggestive of
cancer.

3. Abnormal Pap smear or pelvic examination within the last 9 months suggestive of
cancer.

4. Any uterine or vaginal bleeding within the six months prior to enrollment (except
following the screening Pap smear).

5. Double-wall endometrial thickness that exceeds 5 mm measured on transvaginal
ultrasound.

6. Pregnant or lactating.

7. Use of any vaginal moisturizer (Replens, KY Silk-E, Astroglide Silken Secret,
Senselle) within 30 days of screening.

8. Use of any oral, transdermal, vaginal, or systemic estrogen or estrogen/progestin
product within 30 days of screening.

9. Use of raloxifene, tamoxifen or aromatase inhibitors within 12 weeks of screening.

10. Current urinary tract infection (dipstick urinalysis positive for leukocyte estrace,
nitrates or blood)

11. History of cardiovascular disease.

12. History of venous thromboembolic disease.

13. Use of another investigational agent within 12 weeks of screening.

14. Any medical or psychiatric condition that, in the investigator's opinion, would
preclude the participant from completing questionnaires or measures, adhering to the
protocol or completing the trial, including limited English literacy, severe illness,
plans to move, substance abuse, significant psychiatric problems, or dementia.

15. No access to a telephone