Rivaroxaban Utilization for Treatment and Prevention of Thromboembolism in Cancer Patients: Experience at a Comprehensive Cancer Center

This retrospective descriptive study will review charts of approximately 375 cancer patients
prescribed rivaroxaban from January 1, 2012 to November 7, 2016 at UT MDACC for NVAF or
patients that had prior VTE and diagnosis of cancer. The list of patients prescribed
rivaroxaban during the study period will be obtained from Pharmacy Informatics. We will
review the eligibility of all patients on the pharmacy list who were prescribed rivaroxaban
during the study time-frame. The eligible patients who meet inclusion/exclusion criteria will
be identified. All available data concerning demographic, clinical parameters and rivaroxaban
usage will be collected for eligible patients from Pharmacy Informatics, CS, Laboratory
Informatics, and Clinical Informatics Databases.

The variables of interest include demographic information, clinical parameters (tumor type,
extent of disease, clinical exam findings, and presence of comorbidities, diagnostic
assessments, and treatment interventions), reason for rivaroxaban discontinuation and
outcomes. The confidentiality of all patient-specific data will be maintained. By using
Pharmacy Informatics and CS, we can capture most of patients prescribed rivaroxaban at the UT
MDACC.This is a descriptive study and the final sample size will depend on available records
for chart review from 01/01/2012 to 11/07/2016.

Inclusion Criteria:

1. Age range: patient must be ≥ 18 years.

2. Male and female patients will be eligible for enrollment.

3. Patients diagnosed with deep-vein thrombosis of the lower and upper extremities,
pulmonary embolism or both or with non-valvular atrial fibrillation.

4. Patients must have active malignancy defined as a diagnosis of cancer (excluding basal
cell squamous cell carcinoma of the skin) within six months before enrollment, have
received any treatment for cancer within the previous six months or have documented
recurrent or metastatic cancer .

Exclusion Criteria:

1. Patients who are on hemodialysis

2. Patients with valvular heart disease (using a coexisting prosthetic heart valve or
have a hemodynamically significant valve disease)