Ticagrelor vs. Prasugrel Effects on Infarct Size

Subjects and research staff (including the Magnetic Resonance Imaging (MRI) readers and
interventional cardiologists) will not know what active treatment study drug the subjects
are receiving.

Study Arm 1: Ticagrelor (180 mg loading dose, followed by 90 mg twice a day) PO plus
matching placebo

Study Arm 2: Prasugrel (60 mg loading dose followed by 5 or 10 mg once per day based on
weight) PO plus matching placebo

Additional study drug: Aspirin (81mg per day)

Participation in this study will be about 90 days and includes 4 study visits (other than
your hospital stay) and 3 telephone calls.

ENROLLMENT PROCEDURES:

The following procedures are to be completed after informed consent has been obtained:

- Informed Consent Form signed

- Medical history

- Vital signs (eg, blood pressure, heart rate, respiration rate, temperature)

- Review for Adverse Events (AEs) and Serious Adverse Events (SAEs) (only AEs possibly
related to study procedures and SAEs are collected)

- Documentation of concomitant medications

- Physical exam

- Body height

- Body weight

- 12-lead Electrocardiogram (ECG)

- Angiographic and Percutaneous Coronary Intervention (PCI) data

- Randomization of treatment assignment

- Investigational product dispensing (on Day 0 and during hospital stay) - Loading dose
on Day 0 - 3 day investigational product dosing while in the hospital - 30 day supply
dispensing of investigational product on Day 3 for subject to take home

- Local laboratory Assessments: - Blood draw for Creatine Kinase-MB (CK-MB) and troponin
I - Blood pregnancy (females of childbearing potential only)

FOLLOW UP PROCEDURES:

Day 5

- Vital signs (e.g., blood pressure, heart rate, respiration rate, temperature)

- Review for Adverse Events and Serious Adverse Events (only AEs possibly related to
study procedures and SAEs are collected)

- Cardiac MRI

- Left Ventricular Ejection Fraction (LVEF), Left Ventricular End-Diastolic Volume
(LVEDV), Left Ventricular End-Systolic Volume (LVESV) calculations

- Serum creatinine, Complete Blood Count (CBC)

- Documentation of concomitant medications and investigational product compliance

Day 30 (+/- 1 day), Day 60 (+/- 2 days)

- Vital signs (e.g., blood pressure, heart rate, respiration rate, temperature)

- Review for Adverse Events and Serious Adverse Events (only AEs possibly related to
study procedures and SAEs are collected)

- LVEF, LVEDV, LVESV calculations

- Serum creatinine, CBC

- Documentation of concomitant medications and investigational product compliance

- Investigational Product Dispensing

Day 14, Day 44, Day 74 (+/- 2 days):

Phone calls will be performed to ensure drug compliance, review concomitant medications and
review any events. On Day 74, study staff will confirm whether or not the subject has seen
their regular cardiologist. Subject will be instructed to bring this information with them
at the Day 90 visit so that their cardiologist can be told what arm they participated in for
continuation of care and medication therapy.

Day 90 or Termination/End of Study (+/- 2 days) :

- Vital signs (eg, sitting blood pressure, heart rate, respiration rate, temperature)

- Review for Adverse Events and Serious Adverse Events (only AEs possibly related to
study procedures and SAEs are collected)

- Cardiac MRI

- LVEF, LVEDV, LVESV calculations

- Serum creatinine, CBC

- Documentation of concomitant medications and investigational product compliance

- If available and subject consents, subject's cardiologist will be informed what arm of
the study they participated in for continuation of care and medication therapy.

Inclusion Criteria:

1. Informed consent: Signed informed consent prior to any study specific procedures

2. Age: Male and females aged 18 years and older

3. Onset: Presenting to emergency room or cardiac catheterization laboratory within 6
hours of onset of myocardial infarction symptoms

4. Continuing to have ongoing myocardial infarction symptoms

5. EKG findings: ST elevation on ECG with positive T waves in the precordial leads,
suggestive of anterior STEMI

6. Triaged for emergency cardiac catheterization (primary PCI protocol)

7. Agree to use an effective contraceptive method beginning at the signing of the
informed consent and for at least 30 days after the last dose of study drug. The
definition of an effective method of contraception will be based on the judgment of
the investigator.

Exclusion Criteria:

1. Prior myocardial infarction

2. Contraindication to ticagrelor and/or prasugrel

3. Contraindication to gadolinium

4. Contraindication to aspirin

5. Treatment with fibrinolytic therapy for the index STEMI

6. High risk of bleeding

7. Presenting with cardiogenic shock

8. Infarction due to stent thrombosis

9. History of a previous coronary artery bypass graft (CABG)

10. Known renal insufficiency (acute kidney injury or Glomerular Filtration Rate < 40
mL/min/1.73 m2).

11. Moderate or severe hepatic impairment

12. Inability to undergo cardiac MRI

13. Indication for aspirin >162 mg/d

14. Indication for Nonsteroidal Anti-Inflammatory Drugs or COX2 inhibitors

15. Pregnant

16. Breast feeding

17. History of intracranial hemorrhage