18F-AV-1451 Autopsy Study



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:7/25/2018
Start Date:September 2015
End Date:July 15, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Clinico-Pathological Study of the Correspondence Between 18F-AV-1451 PET Imaging and Post-Mortem Assessment of Tau Pathology

This study is designed to test the relationship between ante-mortem 18F-AV-1451 Positron
Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with
Alzheimer's disease (AD), as measured at autopsy.


Inclusion Criteria:

- Have a projected life expectancy of ≤ 6 months

- Can tolerate a 20 minute PET scan

- Give informed consent or have a legally authorized representative to consent for study
procedures and brain donation consistent with the legal requirements of the State in
which they die

Exclusion Criteria:

- Aggressively being treated with life sustaining measures

- Known to have a structural brain lesion that would interfere either with PET imaging
or pathological assessment

- Clinically significant infectious disease

- Currently receiving any investigational medications except with permission from the
study sponsor

- Participated in an experimental study with an amyloid or tau targeting agent

- Suspected encephalopathy due to alcoholism or end-stage liver disease

- Females of childbearing potential

- History of risk factors for Torsades de Pointes or are currently taking medication
known to cause QT prolongation
We found this trial at
31
sites
D De La Vega MD Research Group
Miami, Florida 33186
Principal Investigator: Dagoberto de la Vega, MD
Phone: 305-552-0203
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Rhode Island Hospital
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Stephen Salloway, MD
Phone: 401-455-6403
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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Emory University Brain Health Center
Atlanta, Georgia 30329
Principal Investigator: William T Hu, MD, PhD
Phone: 404-712-6838
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Atlanta, GA
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Overlake Internal Medicine Associates, PS
1407 116th Avenue Northeast
Bellevue, Washington 98004
Principal Investigator: Allen Geltzer, MD
Phone: 425-372-7320
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Bellevue, WA
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Valley Medical Primary Care
Centerville, Ohio
Principal Investigator: Meenakshi Patel, MD
Phone: 937-208-8298
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Centerville, OH
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Hospice of the Western Reserve
17876 Saint Clair Avenue
Cleveland, Ohio 44119
Principal Investigator: Charles Wellman, MD
Phone: 216-383-3793
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Cleveland, OH
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Murali Doraiswamy, BMMS
Phone: 919-684-5929
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida 33912
Principal Investigator: Frederick W Schaerf, M.D., Ph.D.
Phone: 239-939-7777
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Fort Myers, FL
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Adirondack Medical Research Center
11 Murray Street
Glens Falls, New York 12801
Principal Investigator: Andrew Garner, MD
Phone: 518-798-9401
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Glens Falls, NY
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Steinberg Diagnostics
Henderson, Nevada 89052
Principal Investigator: Upinder Singh, MD
Phone: 702-366-5544
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Henderson, NV
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Galiz Research
Hialeah, Florida 33016
Principal Investigator: Jose Gamez, MD
Phone: 305-805-0921
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Hialeah, FL
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Houston Methodist Research Institute
Houston, Texas 77030
Principal Investigator: Joseph Masdeu, MD, PhD
Phone: 713-441-9484
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Houston, TX
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Sante Clinical Research
Kerrville, Texas 78028
Principal Investigator: Cathy Hurley, MD
Phone: 830-446-6287
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Kerrville, TX
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Cherlin Research
Los Gatos, California 95032
Principal Investigator: Richard Cherlin, MD
Phone: 408-358-2665
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Los Gatos, CA
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Merritt Island Medical Research
Merritt Island, Florida 32952
Principal Investigator: Gregory Kirk, MD
Phone: 321-848-0770
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Merritt Island, FL
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Miami Jewish Health Systems
Miami, Florida 33137
Principal Investigator: Marc Agronin, MD
Phone: 305-751-8626
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Miami, FL
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Hoag Memorial Hospital Presbyterian
Newport Beach, California 92658
Principal Investigator: William Shankle, MD
Phone: 949-764-8190
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Newport Beach, CA
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American Clinical Trials, LLC (Site 1216)
Oklahoma City, Oklahoma 73112
Principal Investigator: Jorg Pahl, MD
Phone: 405-602-1024
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Oklahoma City, OK
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Oklahoma Behavioral Health
Oklahoma City, Oklahoma 73112
Principal Investigator: Marvin Peyton, MD
Phone: 405-334-5408
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Oklahoma City, OK
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Bioclinica
100 West Gore Street
Orlando, Florida 32806
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Orlando, FL
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University of Melbourne
Parkville, Victoria
Principal Investigator: Colin Masters, MD
Phone: 61-3-9035-6650
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Parkville,
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Banner Alzheimer'S Institute
Phoenix, Arizona 85006
Principal Investigator: Allison Perrin, MD
Phone: 602-839-3097
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Phoenix, AZ
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St. Joseph's Hospital and Medical Center
350 W Thomas Rd
Phoenix, Arizona 85013
(602) 406-3000
Principal Investigator: Jiong Shi, MD
Phone: 602-406-3719
St. Joseph's Hospital and Medical Center St. Joseph's is a nationally recognized center for quality...
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Alzheimer's Disease Center
Quincy, Massachusetts 02169
Principal Investigator: Anil Nair, MD
Phone: 617-302-6388
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Quincy, MA
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Pacific Research Network
San Diego, California 92103
Principal Investigator: Stephen Thein, PhD
Phone: 619-294-4302
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San Diego, CA
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California Research Foundation
San Diego, California 92103
Principal Investigator: Donald Brandon, MD
Phone: 619-291-2321
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San Diego, CA
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Ray Dolby Brain Health Center
San Francisco, California 94114
Principal Investigator: Alireza Atri, MD
Phone: 415-600-5555
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San Francisco, CA
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Syrentis Clinical Research
Santa Ana, California 92705
Principal Investigator: John Duffy, MD
Phone: 714-542-3008
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Santa Ana, CA
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University of Washington Medicine
Seattle, Washington 98104
Principal Investigator: Kimiko Domoto-Reilly, MD
Phone: 206-685-3713
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Seattle, WA
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Clarity Clinical Research, LLC
716 East Washington Street
Syracuse, New York 13210
Principal Investigator: Robert Cupelo, MD
Phone: 315-263-3997
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Syracuse, NY
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Wake Forest School of Medicine
Winston-Salem, North Carolina 27157
Principal Investigator: Jamehl Demons, MD
Phone: 336-713-3432
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Winston-Salem, NC
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