18F-AV-1451 Autopsy Study



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:7/25/2018
Start Date:September 2015
End Date:July 15, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Clinico-Pathological Study of the Correspondence Between 18F-AV-1451 PET Imaging and Post-Mortem Assessment of Tau Pathology

This study is designed to test the relationship between ante-mortem 18F-AV-1451 Positron
Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with
Alzheimer's disease (AD), as measured at autopsy.


Inclusion Criteria:

- Have a projected life expectancy of ≤ 6 months

- Can tolerate a 20 minute PET scan

- Give informed consent or have a legally authorized representative to consent for study
procedures and brain donation consistent with the legal requirements of the State in
which they die

Exclusion Criteria:

- Aggressively being treated with life sustaining measures

- Known to have a structural brain lesion that would interfere either with PET imaging
or pathological assessment

- Clinically significant infectious disease

- Currently receiving any investigational medications except with permission from the
study sponsor

- Participated in an experimental study with an amyloid or tau targeting agent

- Suspected encephalopathy due to alcoholism or end-stage liver disease

- Females of childbearing potential

- History of risk factors for Torsades de Pointes or are currently taking medication
known to cause QT prolongation
We found this trial at
31
sites
Rhode Island Hospital
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Stephen Salloway, MD
Phone: 401-455-6403
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Emory University Brain Health Center
Atlanta, Georgia 30329
Principal Investigator: William T Hu, MD, PhD
Phone: 404-712-6838
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Atlanta, GA
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Overlake Internal Medicine Associates, PS
1407 116th Avenue Northeast
Bellevue, Washington 98004
Principal Investigator: Allen Geltzer, MD
Phone: 425-372-7320
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Bellevue, WA
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Valley Medical Primary Care
Centerville, Ohio
Principal Investigator: Meenakshi Patel, MD
Phone: 937-208-8298
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Centerville, OH
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Hospice of the Western Reserve
17876 Saint Clair Avenue
Cleveland, Ohio 44119
Principal Investigator: Charles Wellman, MD
Phone: 216-383-3793
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Murali Doraiswamy, BMMS
Phone: 919-684-5929
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida 33912
Principal Investigator: Frederick W Schaerf, M.D., Ph.D.
Phone: 239-939-7777
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Fort Myers, FL
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Adirondack Medical Research Center
11 Murray Street
Glens Falls, New York 12801
Principal Investigator: Andrew Garner, MD
Phone: 518-798-9401
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Glens Falls, NY
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Steinberg Diagnostics
Henderson, Nevada 89052
Principal Investigator: Upinder Singh, MD
Phone: 702-366-5544
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Henderson, NV
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Galiz Research
Hialeah, Florida 33016
Principal Investigator: Jose Gamez, MD
Phone: 305-805-0921
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Hialeah, FL
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Houston Methodist Research Institute
Houston, Texas 77030
Principal Investigator: Joseph Masdeu, MD, PhD
Phone: 713-441-9484
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Houston, TX
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Sante Clinical Research
Kerrville, Texas 78028
Principal Investigator: Cathy Hurley, MD
Phone: 830-446-6287
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Kerrville, TX
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Cherlin Research
Los Gatos, California 95032
Principal Investigator: Richard Cherlin, MD
Phone: 408-358-2665
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Los Gatos, CA
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Merritt Island Medical Research
Merritt Island, Florida 32952
Principal Investigator: Gregory Kirk, MD
Phone: 321-848-0770
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Miami Jewish Health Systems
Miami, Florida 33137
Principal Investigator: Marc Agronin, MD
Phone: 305-751-8626
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D De La Vega MD Research Group
Miami, Florida 33186
Principal Investigator: Dagoberto de la Vega, MD
Phone: 305-552-0203
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Hoag Memorial Hospital Presbyterian
Newport Beach, California 92658
Principal Investigator: William Shankle, MD
Phone: 949-764-8190
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Newport Beach, CA
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American Clinical Trials, LLC (Site 1216)
Oklahoma City, Oklahoma 73112
Principal Investigator: Jorg Pahl, MD
Phone: 405-602-1024
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Oklahoma Behavioral Health
Oklahoma City, Oklahoma 73112
Principal Investigator: Marvin Peyton, MD
Phone: 405-334-5408
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Bioclinica
100 West Gore Street
Orlando, Florida 32806
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Orlando, FL
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University of Melbourne
Parkville, Victoria
Principal Investigator: Colin Masters, MD
Phone: 61-3-9035-6650
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Banner Alzheimer'S Institute
Phoenix, Arizona 85006
Principal Investigator: Allison Perrin, MD
Phone: 602-839-3097
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St. Joseph's Hospital and Medical Center
350 W Thomas Rd
Phoenix, Arizona 85013
(602) 406-3000
Principal Investigator: Jiong Shi, MD
Phone: 602-406-3719
St. Joseph's Hospital and Medical Center St. Joseph's is a nationally recognized center for quality...
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Alzheimer's Disease Center
Quincy, Massachusetts 02169
Principal Investigator: Anil Nair, MD
Phone: 617-302-6388
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Quincy, MA
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Pacific Research Network
San Diego, California 92103
Principal Investigator: Stephen Thein, PhD
Phone: 619-294-4302
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California Research Foundation
San Diego, California 92103
Principal Investigator: Donald Brandon, MD
Phone: 619-291-2321
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Ray Dolby Brain Health Center
San Francisco, California 94114
Principal Investigator: Alireza Atri, MD
Phone: 415-600-5555
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San Francisco, CA
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Syrentis Clinical Research
Santa Ana, California 92705
Principal Investigator: John Duffy, MD
Phone: 714-542-3008
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Santa Ana, CA
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University of Washington Medicine
Seattle, Washington 98104
Principal Investigator: Kimiko Domoto-Reilly, MD
Phone: 206-685-3713
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Clarity Clinical Research, LLC
716 East Washington Street
Syracuse, New York 13210
Principal Investigator: Robert Cupelo, MD
Phone: 315-263-3997
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Wake Forest School of Medicine
Winston-Salem, North Carolina 27157
Principal Investigator: Jamehl Demons, MD
Phone: 336-713-3432
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