In Vitro Maturation of Human Eggs
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 35 - 45 |
| Updated: | 8/30/2018 |
| Start Date: | July 2015 |
| End Date: | December 2021 |
| Contact: | Lindsey Munkwitz, RN |
| Email: | IVMstudy@colocrm.com |
| Phone: | 303-788-8300 |
Because a large proportion of the embryo's quality is dependent upon the egg, this
investigation focuses on treatment of the oocyte during in vitro maturation (IVM). In typical
IVF cycles, the egg is recovered when it is mature and ready to be fertilized. However, at
this point the oocyte's quality has been set, and cannot be altered. Therefore, to have an
impact on oocyte quality the use of in IVM is critical. Development of a successful IVM
protocol for clinical use would not only provide an option for women of advanced maternal
age, it would also reduce the cost of IVF due to fewer exogenous gonadotropins used for
stimulation, and significantly lessen the risk of ovarian hyper-stimulation.
The objective of this research study is to evaluate a newly developed oocyte maturation media
system for human clinical use in assisted reproductive technology (ART).
investigation focuses on treatment of the oocyte during in vitro maturation (IVM). In typical
IVF cycles, the egg is recovered when it is mature and ready to be fertilized. However, at
this point the oocyte's quality has been set, and cannot be altered. Therefore, to have an
impact on oocyte quality the use of in IVM is critical. Development of a successful IVM
protocol for clinical use would not only provide an option for women of advanced maternal
age, it would also reduce the cost of IVF due to fewer exogenous gonadotropins used for
stimulation, and significantly lessen the risk of ovarian hyper-stimulation.
The objective of this research study is to evaluate a newly developed oocyte maturation media
system for human clinical use in assisted reproductive technology (ART).
The novel device (IVM media system), is designed to support nuclear maturation of immature
oocytes recovered after minimal ovarian stimulation with no LH/hCG administration, and
improve oocyte competence. This may result in development of a greater number of embryos to
the blastocyst stage.
FSH is administered starting on cycle day 3 to stimulate follicle growth. When the leading
follicle reaches 12-14 mm, egg retrieval will be scheduled. No hCG/LH trigger will be
administered. Specially designed maturation media is used to collect and culture the immature
eggs once recovered from the follicle. Once the eggs have matured in vitro, fertilization and
embryo culture, vitrification and comprehensive chromosomal screening will be completed as
per standard operating procedures.
oocytes recovered after minimal ovarian stimulation with no LH/hCG administration, and
improve oocyte competence. This may result in development of a greater number of embryos to
the blastocyst stage.
FSH is administered starting on cycle day 3 to stimulate follicle growth. When the leading
follicle reaches 12-14 mm, egg retrieval will be scheduled. No hCG/LH trigger will be
administered. Specially designed maturation media is used to collect and culture the immature
eggs once recovered from the follicle. Once the eggs have matured in vitro, fertilization and
embryo culture, vitrification and comprehensive chromosomal screening will be completed as
per standard operating procedures.
Inclusion Criteria:
- Infertile women of advanced maternal age (>35 years) who desire to conceive and come
to CCRM for infertility treatment using IVF will be candidates for this study.
- Patients can be of any race, culture, sexual orientation or ethnicity.
Exclusion Criteria:
- Minors are excluded from participation in this study.
- Women whose health is such that becoming pregnant carries risk significantly greater
than healthy women are excluded from this study, unless they use a gestational carrier
under the direction of their physician.
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