Strawberries and Knee Osteoarthritis (OA)



Status:Completed
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:1/20/2018
Start Date:March 2015
End Date:May 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Effects of Freeze-dried Strawberries on Systemic Markers of Inflammation and Knee Function in Participants With Osteoarthritis (OA)

The proposed study aims to examine the hypothesis that strawberry supplementation will lower
serum biomarkers of inflammation and improve knee function in patients with symptomatic
osteoarthritis (OA).

The investigators propose the following two specific aims in a randomized crossover
placebo-controlled trial in participants with two or more features of the metabolic syndrome
and symptomatic osteoarthritis in this 12-week efficacy study:

Aim 1: To assess the effects of strawberries on biomarkers of inflammation [serum levels of
C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β;
tumor necrosis factor-alpha: TNFα] Aim 2: To assess the effects of strawberries on knee
function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and
HAQ-DI).

Inclusion Criteria:

- Clinical diagnosis of knee osteoarthritis

- Must have waist circumference >35 inches for women and >40 inches for men

Exclusion Criteria:

- Cancer

- Heart disease

- Smoking

- Berry allergy
We found this trial at
1
site
Oklahoma State University
Stillwater, Oklahoma
?
mi
from
Stillwater, OK
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