Causes of Comorbid Infertility Among Women With Rheumatoid Arthritis
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Rheumatoid Arthritis, Women's Studies, Infertility |
| Therapuetic Areas: | Rheumatology, Reproductive |
| Healthy: | No |
| Age Range: | 20 - 40 |
| Updated: | 5/5/2017 |
| Start Date: | August 2015 |
| End Date: | January 24, 2017 |
The purpose of this study is to increase our understanding of infertility in women with
Rheumatoid Arthritis (RA). In this study the study team will compare the differences in
ovarian reserve (the ability to provide egg cells that are capable of fertilization), the
frequency of ovulation and the number of pregnancies between women with and without RA. It
is possible that RA activity and medications limit ovarian reserve and ovulation, which may
increase infertility among women with RA. There are several suspected causes for infertility
in RA, including age-related fertility decline, inflammatory changes that impact endometrial
receptivity and discourage implantation, accelerated ovarian decline due to certain
arthritis medications and increased frequency of anovulation (a menstrual cycle during which
ovaries do not release an egg) due to RA activity.
This study is the first step toward our long term goal of increasing the ability of all
women with RA to build the family they desire.
Rheumatoid Arthritis (RA). In this study the study team will compare the differences in
ovarian reserve (the ability to provide egg cells that are capable of fertilization), the
frequency of ovulation and the number of pregnancies between women with and without RA. It
is possible that RA activity and medications limit ovarian reserve and ovulation, which may
increase infertility among women with RA. There are several suspected causes for infertility
in RA, including age-related fertility decline, inflammatory changes that impact endometrial
receptivity and discourage implantation, accelerated ovarian decline due to certain
arthritis medications and increased frequency of anovulation (a menstrual cycle during which
ovaries do not release an egg) due to RA activity.
This study is the first step toward our long term goal of increasing the ability of all
women with RA to build the family they desire.
Inclusion Criteria:
1. RA cohort: Women diagnosed with RA (2010 ACR/EULAR criteria) at least one year prior
to enrollment
2. Healthy cohort: Women without autoimmune disease
Exclusion Criteria:
1. Unilateral or bilateral ovarian surgery
2. Prior exposure to known or possible ovary-toxic medications (e.g., cyclophosphamide,
other chemotherapeutic agents)
We found this trial at
1
site
2301 Erwin Rd
Durham, North Carolina 27710
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Megan Clowse, MD
Phone: 919-681-5871
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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