Prevention of Severe Postpartum Hypertension



Status:Recruiting
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:1/9/2019
Start Date:August 2015
End Date:May 2019
Contact:Shannon A Martin, RN
Email:martins@wudosis.wustl.edu
Phone:314-362-8523

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Furosemide for Prevention of Severe Postpartum Hypertension: a Randomized Controlled Trial

The purpose of this study is to determine whether postpartum administration of furosemide to
women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or
elevated blood pressure in the first 24 hours following delivery reduces severe postpartum
hypertension.


Inclusion Criteria:

Women > 18 years of age or emancipated minors

Women undergoing vaginal or cesarean delivery at > 23 weeks gestation with:

- Antepartum diagnosis of gestational hypertension

- Antepartum diagnosis of preeclampsia

- Antepartum diagnosis of preeclampsia with severe features

- Mild hypertension (<150/100) in first 24 hours following delivery

Exclusion Criteria:

- Chronic hypertension

- Allergy to furosemide

- Pre-existing hypokalemia (serum K < 3.0 meq/L)

- Chronic kidney disease

- Serum Cr > 1.1

- Inability to obtain informed consent

- Pre-existing diuretic use

- Oliguria
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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mi
from
Saint Louis, MO
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