Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 1/18/2019 |
| Start Date: | August 2015 |
| End Date: | December 2018 |
Behavioral Effects of Drugs (Inpatient): 31 (Cocaine and Phendimetrazine)
This study will determine the initial efficacy of phendimetrazine as a pharmacotherapy for
cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which
the subjective, physiological and reinforcing effects of cocaine are evaluated during
maintenance on placebo and phendimetrazine.
cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which
the subjective, physiological and reinforcing effects of cocaine are evaluated during
maintenance on placebo and phendimetrazine.
Inclusion Criteria:
- Recent cocaine use
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular
functioning, chronic obstructive pulmonary disease, history of seizure or current or
past histories of serious psychiatric disorder that in the opinion of the study
physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine or phendimetrazine
We found this trial at
1
site
Lexington, Kentucky 40536
Principal Investigator: William W Stoops, Ph.D.
Phone: 859-257-5388
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