OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

This is a longitudinal observational study in which individuals (males and females 3 years of
age and greater) with EoE, EG, and EC will be followed over the course of time to see if
standard questionnaires can give us an idea of how well the person is doing.

Participants undergoing standard of care (normal, routine care) endoscopies and/or
colonoscopies will have biopsies (small pieces of tissue from the GI tract normally collected
during these procedures) collected and used for the research study. Participants will also
complete questionnaires related to their symptoms and quality of life. Participants will be
followed over the course of time and asked to complete the questionnaires at various time
points throughout the study.

Inclusion Criteria:

- Males or females 3 years of age and older

- Mucosal eosinophilia (≥15 eos/hpf for EoE, ≥30 eos/hpf for EG, ≥32 eos/hpf for EC)

- Presence of symptoms is required for patients who are newly diagnosed but not required
for patients who were previously diagnosed

- EC patients must have a history of one of the following at the time of colonoscopy:

1. anemia

2. peripheral eosinophilia

3. hemoccult positive stool

4. EGID

5. allergic disease (allergic rhinitis, asthma, food allergy, eczema or other
allergic features suggestive of atopic disease)

Exclusion Criteria:

- History of intestinal surgery other than G tube placement

- Enrolled in a blinded investigational study

- Have esophageal stricture (<3mm)

- Have other identifiable causes for eosinophilia (except Inflammatory Bowel Disease):
infections, Gastrointestinal (GI) cancer, other GI inflammatory disease (e.g.,
Ulcerative Colitis or Crohn's Disease)