Resveratrol and Exercise to Treat Functional Limitations in Late Life

This investigation is a pilot study to investigate the potential of resveratrol, a
commercially-available nutritional product, to enhance the efficacy of physical exercise in
improving physical function among older adults with functional limitations. The overarching
objective of this project is to evaluate the safety and efficacy of an intervention combining
resveratrol supplementation and physical exercise among sedentary persons aged > 65 years
objectively-measured functional impairments. A total of 60 participants will be recruited to
participate in this three month intervention study. All participants will engage in a
center-based exercise program 3/days per week and will be randomly assigned to consume 1)
placebo, 2) 250 mg/day resveratrol, or 3) 1000 mg/day resveratrol. This study will provide
critical information regarding the influence of the combination of resveratrol and exercise
on objectively-measured and self-assessed indices of physical function. The study will also
provide novel biologic information regarding the relative effects of the interventions on
skeletal muscle mitochondrial function.

Inclusion Criteria:

- Ability to understand study procedures and to comply with them for the entire length
of the study

- Willingness to be randomized into either treatment group

- Age 65 years and older

- Physical limitations evidenced by >290 seconds needed to complete long-distance
corridor walk test

- Sedentary lifestyle, defined as <150 min/wk of moderate physical activity as assessed
by CHAMPS questionnaire

Exclusion Criteria:

- Failure to provide informed consent

- Regular consumption of a resveratrol supplement

- Current involvement in supervised rehabilitation program

- Absolute contraindication(s) to exercise training according to American College of
Sports Medicine guidelines

- Pain classification > Grade 3 on Graded Chronic Pain Scale

- Peripheral vascular disease; peripheral neuropathy; retinopathy

- Severe cardiac disease, including:

NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis,
history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina

- Myocardial infarction or stroke within past year

- Significant cognitive impairment, including:

known dementia diagnosis or a Mini-Mental State Examination exam score <24

- Progressive, degenerative neurologic disease (e.g., Parkinson's Disease, multiple
sclerosis, ALS)

- Severe rheumatologic or orthopedic diseases (e.g., awaiting joint replacement, active
inflammatory disease)

- Severe pulmonary disease, requiring either steroid pills or injections or the use of
supplemental oxygen

- Hip fracture, hip or knee replacement, or spinal surgery within past 4 mos.

- Other significant co-morbid conditions that would impair ability to participate in the
exercise-based intervention

- Simultaneous participation in another intervention trial