Relationships Among Cognitive Function, Lifestyle, and Exercise After Cancer Treatment
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer, Cognitive Studies, Cognitive Studies |
| Therapuetic Areas: | Oncology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 10/8/2017 |
| Start Date: | July 2015 |
| End Date: | July 31, 2017 |
The purpose of this study is to examine relationships among lifestyle behaviors (i.e.,
physical activity, sleep), cognitive function (i.e., memory, processing speed, and executive
function), and quality of life in breast cancer patients and survivors across time. The
investigators will compare the strength of these relationships across age cohorts and time
since treatment and diagnosis. Participants will complete a battery of questionnaires and a
set of cognitive tests on an iPad app specifically tailored for this study. A subset of
participants will also wear an accelerometer for seven days. Data will be collected at
baseline and 6-month follow-up.
This research is critical to identifying potentially important approaches to improving health
outcomes and quality of life in breast cancer patients and survivors. Previous research
provides evidence of the influence of lifestyle behaviors on cognition and quality of life in
healthy aging populations. However, despite data indicating cancer's negative impact on
lifestyle behaviors, cognition, and quality of life, very few studies have investigated
interactions among these factors in cancer patients and survivors.
physical activity, sleep), cognitive function (i.e., memory, processing speed, and executive
function), and quality of life in breast cancer patients and survivors across time. The
investigators will compare the strength of these relationships across age cohorts and time
since treatment and diagnosis. Participants will complete a battery of questionnaires and a
set of cognitive tests on an iPad app specifically tailored for this study. A subset of
participants will also wear an accelerometer for seven days. Data will be collected at
baseline and 6-month follow-up.
This research is critical to identifying potentially important approaches to improving health
outcomes and quality of life in breast cancer patients and survivors. Previous research
provides evidence of the influence of lifestyle behaviors on cognition and quality of life in
healthy aging populations. However, despite data indicating cancer's negative impact on
lifestyle behaviors, cognition, and quality of life, very few studies have investigated
interactions among these factors in cancer patients and survivors.
Interested individuals will visit the ReFLECT Study website (www.reflectstudies.org) to learn
more about the study and receive instructions on how to participate. Individuals will be
instructed to create a username (email address) and password for BrainBaseline©
(www.BrainBaseline.com; Digital Artefacts, Iowa City, IA). While BrainBaseline© is a
commercially available mobile app, a version specifically tailored for this study will be
used. The website directions will include information on how to download the BrainBaseline©
iPad app (for ReFLECT) from the iTunes store. Each time a participant closes and reopens the
iPad app, she will be required to enter her BrainBaseline© username and password. Upon
opening the iPad app for the first time, the individual will be asked to confirm their
eligibility for the study. If eligible, the individual will proceed to the consent form.
Participants will electronically sign the Institutional Review Board-approved informed
consent form before completing a battery of questionnaires assessing demographics, medical
history, physical activity, sedentary behavior, sleep, fatigue, quality of life, satisfaction
with life, depressive symptoms, and perceived memory. Individuals cannot view the
questionnaires until they have electronically signed the consent form. Participants will also
be asked to complete a set of ten evidence-based cognitive tests assessing attention, speed
of processing, and executive function. Descriptions of the tests are available at
www.BrainBaseline.com/assessments. The questionnaires are expected to take approximately 45
minutes and the cognitive tests are expected to take approximately 60 minutes to complete.
Participants will be instructed to complete the questionnaires and cognitive tests within two
weeks of signing the consent form. The onscreen instructions and consent form will also
notify participants that a) they do not have to complete either the questionnaires or the
cognitive tests in one sitting, but can return to them during the course of the week, and b)
they can move back and forth between the questionnaires and cognitive tests (i.e., do not
need to finish one section before moving to the next). Reminder emails will be sent on days 7
and 10 to remind participants to complete assessments.
A subset of participants who volunteer to do so will also wear an accelerometer for 24 hours
per day for 7 consecutive days to objectively measure activity levels and sleep quality.
Individuals will be asked if they are willing to be contacted to wear the accelerometer via
the consent form. Only those individuals who check the box agreeing to be contacted by the
research team will be contacted to wear the accelerometer (see consent form). Participants
will be contacted via email and instructed to reply to the researcher by phone or email with
their mailing address. The accelerometer, instructions for wear, a Record of Use form, and a
postage-paid return envelope will be mailed to participants who agree to wear the monitor.
Mailing labels from postage-paid return envelopes will be disposed of after accelerometers
have been returned and recorded. The accelerometer will be worn during women's daily life on
a normal week; therefore, minimal additional time committed to research activities will be
required of participants. No contact will be solicited with participants over the course of
the 6-month study period.
more about the study and receive instructions on how to participate. Individuals will be
instructed to create a username (email address) and password for BrainBaseline©
(www.BrainBaseline.com; Digital Artefacts, Iowa City, IA). While BrainBaseline© is a
commercially available mobile app, a version specifically tailored for this study will be
used. The website directions will include information on how to download the BrainBaseline©
iPad app (for ReFLECT) from the iTunes store. Each time a participant closes and reopens the
iPad app, she will be required to enter her BrainBaseline© username and password. Upon
opening the iPad app for the first time, the individual will be asked to confirm their
eligibility for the study. If eligible, the individual will proceed to the consent form.
Participants will electronically sign the Institutional Review Board-approved informed
consent form before completing a battery of questionnaires assessing demographics, medical
history, physical activity, sedentary behavior, sleep, fatigue, quality of life, satisfaction
with life, depressive symptoms, and perceived memory. Individuals cannot view the
questionnaires until they have electronically signed the consent form. Participants will also
be asked to complete a set of ten evidence-based cognitive tests assessing attention, speed
of processing, and executive function. Descriptions of the tests are available at
www.BrainBaseline.com/assessments. The questionnaires are expected to take approximately 45
minutes and the cognitive tests are expected to take approximately 60 minutes to complete.
Participants will be instructed to complete the questionnaires and cognitive tests within two
weeks of signing the consent form. The onscreen instructions and consent form will also
notify participants that a) they do not have to complete either the questionnaires or the
cognitive tests in one sitting, but can return to them during the course of the week, and b)
they can move back and forth between the questionnaires and cognitive tests (i.e., do not
need to finish one section before moving to the next). Reminder emails will be sent on days 7
and 10 to remind participants to complete assessments.
A subset of participants who volunteer to do so will also wear an accelerometer for 24 hours
per day for 7 consecutive days to objectively measure activity levels and sleep quality.
Individuals will be asked if they are willing to be contacted to wear the accelerometer via
the consent form. Only those individuals who check the box agreeing to be contacted by the
research team will be contacted to wear the accelerometer (see consent form). Participants
will be contacted via email and instructed to reply to the researcher by phone or email with
their mailing address. The accelerometer, instructions for wear, a Record of Use form, and a
postage-paid return envelope will be mailed to participants who agree to wear the monitor.
Mailing labels from postage-paid return envelopes will be disposed of after accelerometers
have been returned and recorded. The accelerometer will be worn during women's daily life on
a normal week; therefore, minimal additional time committed to research activities will be
required of participants. No contact will be solicited with participants over the course of
the 6-month study period.
Inclusion Criteria:
- Female diagnosed with breast cancer
- 21 years or older
- English speaking
- Access to an iPad with iOS 6.2 or later and the Internet
Exclusion Criteria:
- Male
- Individuals under 21 years of age
- Individuals who do not have access to an iPad with iOS 6.2 or later
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