A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee

The purpose of this clinical study is to collect information on the effectiveness of CR845
and to look at the safety of different dose levels of CR845 tablets. Oral CR845 has been
tested in healthy people. This is the first time that oral CR845 is being tested in patients
with osteoarthritis.

Four different doses of CR845 will be tested in this study. Participants will be assigned to
one of the four treatment groups. The first 6 participants in each of the 4 treatment groups
will be given the study drug in an inpatient study unit (clinic) for approximately 2 days.
Frequent blood samples will be taken to measure drug levels during these 2 days. Also,
because the study drug (CR845) is known to increase urination during the first day, the
amount of fluid that participants drink and the amount of urine that they void during the
first day will also be measured.

At the end of the second day, a member of the clinical staff will check vital signs and the
patient's laboratory results prior to discharge from the clinic. After that, the remainder
of the treatment period is as an outpatient (at home). This involves taking an additional
two tablets twice a day, and maintaining a diary that will be returned to the clinic upon
completion.

Inclusion Criteria:

A patient will be eligible for enrollment if the following criteria are met:

1. Voluntarily provides written informed consent to participate in the study prior to
any study procedures.

2. Is able to speak, read, and communicate clearly in English or Spanish; is able to
understand the study procedures.

3. Male or female ≥ 25 years of age.

4. BMI ≤ 40

5. Has OA of the hip or knee according to American College of Rheumatology (ACR)
criteria.

6. Reports an average pain intensity level ≥ 4 in the index joint at Screening on an
NRS.

7. Willing to discontinue currently used pain medications beginning 5 days prior to the
Baseline Visit and throughout the study.

8. If female:

1. Of childbearing potential - the patient must be willing to practice an
acceptable form of birth control (defined as the use of an intrauterine device;
a barrier method with spermicide; condoms, any form of hormonal contraceptives;
or abstinence from sexual intercourse) for the duration of treatment and for at
least 3 days following the last dose of study drug.

2. Of non-childbearing potential - the patient must be surgically or biologically
sterile (hysterectomy, bilateral oophorectomy, bilateral tubal ligation, or
postmenopausal for at least 1 year).

9. If male, the patient must be surgically or biologically sterile. If not sterile, the
patient must agree to use an acceptable form of birth control with a heterosexual
partner (as described in inclusion criterion #8) or abstain from sexual relations
during the treatment period and for 3 days following the last dose of study drug.

10. Is free of other physical, mental, or medical conditions, which, in the opinion of
the Investigator, would make study participation inadvisable.

11. Reports average daily pain intensity ≥ 4 in the index joint during the 3 days prior
to Baseline on the NRS.

Exclusion Criteria:

- A patient will be excluded from enrollment if the patient meets any of the following
criteria:

1. Has had a joint replacement in the index joint.

2. Has received an intra-articular injection of corticosteroids or hyaluronic acid
in the index joint within 3 months prior to the Screening Visit.

3. Has started a new medication for chronic illness within 30 days prior to the
Screening Visit.

4. Has a history or current diagnosis of substance dependence (except caffeine or
nicotine) or alcohol abuse, according to the criteria of the Diagnostic and
Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).

5. Has a positive urine drug screen for drugs of abuse at Screening or Baseline.

6. Has been diagnosed with a condition of hyperhidrosis or primary hypodipsia.

7. Has a history (within 6 months) of clinically meaningful orthostatic changes in
vital signs, OR, at Screening, has a decrease in systolic blood pressure by > 20
mm Hg or a decrease in diastolic blood pressure by 10 mm Hg together with an
increase in heart rate of > 30 beats per minute when transitioning from supine
to standing measurements.

8. Has a medical condition (e.g., a cardiovascular, pulmonary, hepatic, renal,
hematologic, gastrointestinal, endocrine [adrenal hyperplasia], immunologic,
dermatologic, neurologic, oncologic, or psychiatric condition) or a significant
laboratory abnormality that, in the Investigator's opinion, would jeopardize the
safety of the patient or is likely to confound the study measurements.

9. Has a serum sodium level > 145 mmol/L at Screening.

10. Has impaired renal function indicated by serum creatinine > 2 × the reference
upper limit of normal (ULN).

11. Has a serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >
2.5 × the reference ULN, or total bilirubin > 2 × the ULN at Screening.

12. Has, in the opinion of the Investigator, any clinical signs of dehydration or
hypovolemia (e.g., symptomatic hypotension) or associated laboratory
abnormalities (e.g., elevated hematocrit or elevated blood urea nitrogen [BUN] >
1.5 × the reference ULN) at Screening.

13. Has taken opioid or non-opioid pain medication (e.g., nonsteroidal
anti-inflammatory drugs [NSAIDs] such as naproxen or cyclooxygenase-2
inhibitors) within 5 days prior to study drug administration.

14. Has received another investigational drug within 30 days prior to Baseline or
has planned to participate in another clinical trial while enrolled in this
study.