The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial

240 participants, aged 55 or above, will be recruited (120 Norwich, 120 Melbourne; to
include both MCI and SCI participants).

Participants will be asked to take the study food each day for 12 months, and to come to the
clinical assessment unit on 3 occasions, at baseline, 3 months and 12 months, to complete a
cognitive task battery such that their performance may be investigated in the context of the
intervention.

Urine, blood and faecal samples will be collected and magnetic resonance imaging (MRI) will
be applicable to half of each population (i.e to 60 MCI and 60 SCI, 30 of each at Norwich
and Melbourne).

Inclusion Criteria:

- Male and female, aged ≥ 55 years

- Mild cognitive impairment (MCI) or subjective memory impairment (SMI) with no
indication of clinical dementia or depression

- Willing and able to provide written informed consent.

- Understands and is willing and able to comply with all study procedures.

- Fluent in written and spoken English.

- In good general health including blood biochemical, haematological and urinalysis
within the normal range at screening (as judged by the clinical advisor)

- Normal, or corrected to normal vision and hearing

- Right handed, for MRI

- Stable use of any prescribed medication for at least four weeks

Exclusion Criteria:

- Diagnosis of Alzheimer's disease (AD) or other form of dementia or significant
neurological disorder

- Parent or sibling who developed premature dementia <60y (suggestive of a familial
monogenic form of cognitive decline)

- Past history or MRI evidence of brain damage including significant trauma, stroke,
learning difficulties or serious neurological disorder, including loss of
consciousness > 24 hours

- History of alcohol or drug dependency within the last 2 years

- Other clinically diagnosed psychiatric disorder likely to affect the cognitive
measures (as judged by clinical adviser)

- Existing diagnosed gastrointestinal disorders likely to impact on absorption of
flavonoids and fatty acids (as judged by clinical adviser)

- Major cardiovascular event, e.g. myocardial infarction or stroke, in the last 12
months

- Carotid stents or severe stenosis

- Known allergy to fish or any other component in the intervention supplements

- Existing medical conditions likely to affect the study measures (as judged by
clinical adviser)

- Uncontrolled hypertension (Systolic Blood Pressure (SBP) >140mmHg, Diastolic Blood
Pressure (DBP) >90mmHg)

- BMI >40kg/m2