Heart Rate Variability in Depression

Status:	Recruiting
Conditions:	Depression, Depression, Major Depression Disorder (MDD)
Therapuetic Areas:	Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:	No
Age Range:	18 - 65
Updated:	8/30/2018
Start Date:	July 2015
End Date:	August 2019
Contact:	Andrea Crowell, MD
Email:	andrea.crowell@emory.edu
Phone:	404-727-2397

Relationship Between Heart Rate Variability and Emotional Experience in Healthy and Depressed Adults

The purpose of this study is to understand if there is a relationship between the way that
emotions are regulated by the brain and the way that heart rate is regulated by the brain.
The study also seeks to understand whether having depression changes the way that emotions
and heart rate are regulated.

Inclusion Criteria:

- Ages 18-65 years

- Able to understand and provide informed consent

- Male and female

Depressed Subjects:

- Current diagnosis of major depressive disorder (MDD) and currently in an major
depressive episode (MDE)

- Quick Inventory of Depressive Symptomology (QIDS-SR16) score of 11 or greater

- Anticipated treatment with ketamine infusion for depression

Exclusion Criteria:

- Current daily use of tricyclic antidepressants

- Current diagnosis of cardiac arrhythmia or heart failure

- Pregnancy

- Current use of cardiac medications of the class beta-blockers

- Current treatment with deep brain stimulation for any reason

Healthy Controls:

- Current psychiatric treatment, including use of antidepressants or daily use of
anxiolytic medication

Depressed Subjects:

- Previous history of ketamine infusion for depression

- Psychotic symptoms

- Active co-morbid psychiatric diagnosis including anxiety disorder or personality
disorder that significantly affects the current clinical condition, as determined by
medical records

We found this trial at

sites

12 Executive Park Drive

Atlanta, Georgia 30329

Phone: 404-727-2397

from

Atlanta, GA