Feasibility Study Incorporating Lung Function Imaging Into Radiation Therapy for Lung Cancer Patients

This study plans to learn more about radiation therapy. Radiation therapy is one of the main
treatments used to treat lung cancer. One of the known side effects of this radiation therapy
is scarring of the lungs and reduced lung function that can result in shortness of breath. At
this time the radiation treatment plan does not take into account differences in lung
function between one part of the lung and another. Studies have shown that lung function can
vary substantially throughout the lungs. This study aims to plan the radiation therapy to be
away from the highest functioning portions of lungs while still delivering the intended
radiation dose to the tumor. This study will allow researchers to determine whether taking
lung function information into account when designing radiation treatment plans can protect
lung function after radiation therapy.

Inclusion Criteria:

1. Diagnosis of pathologically confirmed lung cancer by tumor biopsy and/or fine-need
aspiration

2. Lung Cancer patients that will undergo definitive radiation therapy defined as 45-75
Gy as part of standard of care for their disease

3. 18 years of age or older

4. Signed informed consent

5. Planned curative intent chemotherapy, delivered concurrently or sequentially in
combination with radiotherapy

6. The patient's 4DCT-ventilation image meets image heterogeneity criteria

Exclusion Criteria:

1. Patients receiving Stereotactic Body Radiation Therapy

2. Patient receiving palliative radiation therapy (defined as less than 45 Gy)