WISER After Ovarian Cancer - Exercise Pilot Study
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Ovarian Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2015 |
One in four deaths in the United States is due to cancer, and one in three women will
develop cancer in her lifetime. Despite improvements in survival among other forms of
cancer, ovarian cancer prognosis remains poor. Eighty percent of women with ovarian cancer
will present with advanced disease (stage 3 or 4) where 5-year survival ranges from 18-34%.2
Among patients with stage III and IV epithelial ovarian cancer (EOC), recurrence rates are
high.4 Therefore, interventions focused on preventing recurrence or slowing progression of
EOC is a critical problem in the field. The investigators have submitted an R21 to NCI for a
dose response exercise intervention trial to examine the dose response effects of aerobic
exercise on biomarkers relevant to ovarian cancer progression and recurrence. The reviewers
would like assurance that the investigators can recruit ovarian cancer patients into an
exercise study and that these women will do the exercise protocol we plan to prescribe in
our high dose of exercise.
develop cancer in her lifetime. Despite improvements in survival among other forms of
cancer, ovarian cancer prognosis remains poor. Eighty percent of women with ovarian cancer
will present with advanced disease (stage 3 or 4) where 5-year survival ranges from 18-34%.2
Among patients with stage III and IV epithelial ovarian cancer (EOC), recurrence rates are
high.4 Therefore, interventions focused on preventing recurrence or slowing progression of
EOC is a critical problem in the field. The investigators have submitted an R21 to NCI for a
dose response exercise intervention trial to examine the dose response effects of aerobic
exercise on biomarkers relevant to ovarian cancer progression and recurrence. The reviewers
would like assurance that the investigators can recruit ovarian cancer patients into an
exercise study and that these women will do the exercise protocol we plan to prescribe in
our high dose of exercise.
Inclusion Criteria:
- Diagnosis of stage III-IV EOC, completed surgery,
- > 12 months life expectancy (physician estimate),
- able to walk 15 minutes at a time (use of a cane is acceptable).
Exclusion Criteria:
- medical or psychiatric conditions (beyond ovarian cancer, its treatment, and its
symptoms) that would impair our ability to test study hypotheses (e.g. cardiac,
pulmonary, or
- orthopedic history that would prohibit a program of walking for exercise;
- psychotic disorders,
- dementia,
- inability to give informed consent
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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