TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence
| Status: | Completed |
|---|---|
| Conditions: | Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 5/19/2018 |
| Start Date: | August 15, 2015 |
| End Date: | March 31, 2018 |
Transcranial Direct Current Stimulation (TDCS) and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence
The purpose of the phase 1 translational pilot study proposed here is to gather preliminary
data investigating the efficacy of transcranial direct current stimulation (TDCS) and
cognitive retraining to enhance nicotine replacement therapy for smoking cessation. The
recent use of TDCS over task relevant regions to alter behavior holds incredible promise for
use in cognitive retraining intervention protocols. Previous studies of cognitive retraining
have focused on implicit training techniques. This proposed study will attempt to enhance
these implicit training techniques through the use of TDCS during implicit retraining in
order to increase learning of avoidance-related action tendencies towards tobacco. The
objective of this pilot study is to establish the feasibility and obtain preliminary data on
the effectiveness of using brain stimulation with cognitive retraining to reduce cigarette
smoking in individuals with nicotine addiction.
data investigating the efficacy of transcranial direct current stimulation (TDCS) and
cognitive retraining to enhance nicotine replacement therapy for smoking cessation. The
recent use of TDCS over task relevant regions to alter behavior holds incredible promise for
use in cognitive retraining intervention protocols. Previous studies of cognitive retraining
have focused on implicit training techniques. This proposed study will attempt to enhance
these implicit training techniques through the use of TDCS during implicit retraining in
order to increase learning of avoidance-related action tendencies towards tobacco. The
objective of this pilot study is to establish the feasibility and obtain preliminary data on
the effectiveness of using brain stimulation with cognitive retraining to reduce cigarette
smoking in individuals with nicotine addiction.
Inclusion Criteria:
- Consume 10 or more cigarettes/day average for the past 60 days
- Able to provide informed consent
- Less than 3 months smoking abstinence in the past year
- Right Handed
Exclusion Criteria:
- Serious medical illness within 6 months (e.g. cancer, hepatic, or renal disease)
- Significant cardiovascular disease (e.g. recent stroke or heart attack, arrhythmias,
worsening angina pectoris, uncontrolled hypertension) generalized skin disorders, or
sensitivity to the nicotine patch
- Use of illicit drugs (excluding marijuana) in the previous 30 days
- Psychosis, psychotic disorder, or bipolar disorder
- Current active major depression (depressive episode within last month)
- Clinically significant suicidal ideation
- Prior seizure
- Current bupropion or tricyclic antidepressants
- Current pregnancy, trying to become pregnant, or breastfeeding
- Current active alcohol dependence (symptoms in last 30 days)
- Left-handedness
- Current medication known to interact with nicotine replacement therapy (NRT) or
smoking cessation (e.g. adenosine, cimetidine, conivaptan, cyproterone, peginterferon
alfa-2bg, tocilizumab, theophylline)
- Metal in the head
- Implanted brain medical devices
- Electromedical devices
- Latex Allergy
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